Search for dissertations about: "cell cycle checkpoint"

Showing result 1 - 5 of 37 swedish dissertations containing the words cell cycle checkpoint.

  2. 1. Cell cycle regulation in cancer: A noncoding perspective

    Author : Mohamad Ali; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Long Noncoding RNA; lncRNA; Cell cycle; S phase; Mitosis; Checkpoint; Cancer; SCAT7; LY6K-AS;

    Abstract : The cell cycle progression is tightly regulated to ensure error-free cell replication. The complexity of the transcriptional machinery aids to function in a spatiotemporal pattern across different phases and genomic loci. READ MORE

  4. 2. Optimizing experimental radioimmunotherapy : investigating the different mechanisms behind radiation induced cell deaths

    Author : Theres Lindgren; David Eriksson; Torgny Stigbrand; Bo Stenerlöw; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mitotic catastrophe; senescence; cell cycle checkpoint; apoptosis; radiation; gene expression; p53; immunologi; Immunology; radiofysik; radiation physics;

    Abstract : Background. Radiation therapy is an important treatment regimen for malignant disease. Radiation therapy uses ionizing radiation to induce DNA damage in tumor cells in order to kill them. READ MORE

  5. 3. DNA precursor asymmetries, Mismatch Repair and their effect on mutation specificity

    Author : Robert Buckland; Andrei Chabes; Juan Méndez; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA Replication Fidelity; Mutations; dNTP pools; Mismatch Repair; Checkpoint; Ribonucleotide Reductase; Msh2; medicinsk biokemi; Medical Biochemistry; molekylärbiologi; Molecular Biology;

    Abstract : In order to build any structure, a good supply of materials, accurate workers and quality control are needed. This is even the case when constructing DNA, the so-called “Code of Life.” For a species to continue to exist, this DNA code must be copied with incredibly high accuracy when each and every cell replicates. READ MORE

  6. 4. DNA checkpoint override and redox signaling in Schizosaccharomyces pombe

    Author : Johanna J Sjölander; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Caffeine; Cell cycle; Checkpoint; Cdc25; Wee1; TORC1; FHIT; Proliferation; Aph1; Redox; Hypoxia; H2O2; Cysteine; Thiol; Allosteric; MAPK; Sty1; MAPKK; Wis1;

    Abstract : This thesis covers intracellular stress signaling through genotoxic stress, overriding of checkpoint control, as well as cellular redox status in hypoxic and oxidative stress Papers I and II: Caffeine has been shown to override cell cycle checkpoints in humans as well as in the fission yeast Schizosaccharomyces pombe. Understanding of the mechanism may aid in the development of compounds with similar overriding mechanisms for sensitization in cancer therapy. READ MORE

  7. 5. The Heterogenic Final Cell Cycle of Retinal Horizontal Cells

    Author : Shahrzad Shirazi Fard; Finn Hallböök; Ulla Pirvola; Uppsala universitet; []
    Keywords : Apoptosis; Checkpoint; DNA damage; Differentiation; Heteroploid; Endoreplication; Proliferation; Tumor; Neuroscience; Neurovetenskap;

    Abstract : The cell cycle is a highly complex process that is under the control of several pathways.  Failure to regulate and/or complete the cell cycle often leads to cell cycle arrest, which may be followed by programmed cell death (apoptosis). One cell type that has a variety of unique cell cycle properties is the horizontal cell of the chicken retina. READ MORE