Search for dissertations about: "cell-mediated cytotoxicity"

Showing result 1 - 5 of 39 swedish dissertations containing the words cell-mediated cytotoxicity.

  2. 1. Triggering and mechanisms of natural killer cell mediated cytotoxicity

    Author : Yenan Bryceson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Natural killer cells; antibody dependent cellular cytotoxicity; natural cytotoxicity; immunodeficiency; hemophagocytic lymphohistiocytosis;

    Abstract : Natural killer (NK) cells are innate immune cells that contribute to defense against infected and transformed cells by target cell killing and cytokine release. In addition, data suggest that NK cells contribute to immune homeostasis and reproduction. READ MORE

  4. 2. Flow cytometric methods for assessment of cell-mediated immune responses

    Author : Karina Godoy Ramirez; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Flow cytometry; intracellular cytokine staining ICS ; NK cell; CTL; cytotoxicity; HIV-1;

    Abstract : The aim of this thesis was to develop and improve flow cytometry-based methods for assessment of cellmediated immune responses (CMI) induced by natural infection or vaccination. Traditionally, the measurement of anti genspecific cellular immune responses has been based on the use of complex, labourintensive, and less informative bulkresults assays (51Cr-release, 3 3H-thymidin uptake and Limiting dilution assay, LDA). READ MORE

  5. 3. Molecular specificities of NK cell-mediated recognition of human tumor cells

    Author : Mattias Carlsten; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Natural killer (NK) cells have been implicated in tumor immune surveillance and can reject transformed cells expressing ligands for activating NK cell receptors and low levels of HLA class I. Although NK cells are well known for their ability to kill tumor cells, relatively few studies have addressed the molecular specificity of NK cell-mediated recognition of freshly isolated human tumor cells. READ MORE

  6. 4. On cellular immunology in chronic idiopathic thrombocytopenic purpura (ITP)

    Author : Per-Ola Andersson; Göteborgs universitet; []
    Keywords : chronic ITP; T-cells; TGF-b1; Th3; cell-mediated cytotoxicity; KIR; DNA microarray;

    Abstract : Chronic idiopathic thrombocytopenic purpura (ITP) is an acquired autoimmune disease characterized by a low platelet count and mucocutaneous bleedings. Chronic ITP is considered to be mediated by autoantibodies leading to premature destruction of platelets in the reticuloendothelial system. READ MORE

  7. 5. Human intestinal T lymphocytes : a comparative analysis of phenotype and function in normal and inflamed mucosa

    Author : Silvia Melgar; Nadine Cerf-Bensussan; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human intestinal mucosa; intraepithelial lymphocyte; lamina propria lymphocyte; γδ T cell; regulatory T cell; cytotoxicity; cytokine; basal lymphoid aggregate; ulcerative colitis; Crohn s disease;

    Abstract : The epithelial lining of the gut must allow immediate contact with beneficial components as nutrients and normal microflora. At the same time it runs the constant risk of attack from pathogenic microbes and noxious agents. READ MORE