Search for dissertations about: "central hyperexcitability"

Showing result 1 - 5 of 10 swedish dissertations containing the words central hyperexcitability.

2. 1. Mechanisms of excitability in the central and peripheral nervous systems : Implications for epilepsy and chronic pain

   Author : Jenny Tigerholm; Erik Fransén; Dieter Jaeger; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Dendritic excitability; synchronized synaptic input; multicompartment model; epilepsy; axonal excitability; silent C–fibres; Hodgkin–Huxley dynamics; conduction velocity; KA;

   Abstract : The work in this thesis concerns mechanisms of excitability of neurons. Specifically, it deals with how neurons respond to input, and how their response is controlled by ion channels and other active components of the neuron. READ MORE

4. 2. Experimental Aspects on Chronic Whiplash-Associated Pain

   Author : Dag Lemming; Björn Gerdle; Per Hansson; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neck injury; whiplash-associated disorders; chronic pain; central sensitization; pain assessment; drug challenges; MEDICINE; MEDICIN;

   Abstract : Introduction: Chronic pain after whiplash trauma (chronic WAD) to the neck is still a common clinical problem in terms of pain management, rehabilitation and insurance claims. In contrast to the increased knowledge concerning mechanisms of chronic pain in general, no clinical guidelines exist concerning assessment, pain control and rehabilitation of patients with chronic WAD. READ MORE

5. 3. Comprehensive evaluation of spasticity and other sensorimotor dysfunctions after lesions to the central or peripheral nervous system

   Author : Gaia Valentina Pennati; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Background: Understanding how sensorimotor impairments may contribute to changes in body structure and function, and also to activity and participation limitations is an important challenge in neurorehabilitation research, of high clinical relevance. Available assessment methods include mainly clinical scales, often with inadequate psychometric properties, such as the Modified Ashworth scale for assessment of spasticity. READ MORE

6. 4. Experimental and clinical studies on adenosine receptor stimulation in cutaneous hypersensitivity and neuropathic pain

   Author : Karl-Fredrik Sjölund; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Adenosine agonists; allodynia; central sensitization; hyperalgesia; nociception; pain;

   Abstract : The endogenous compound adenosine (ADO) has a wide range of physiological effects. Numerous animal studies and a limited number of human studies have shown antinociceptive effects of ADO and its analogues. The spinal cord dorsal column, where ADO receptors are found in high numbers, is a major site of action for this effect. READ MORE

7. 5. Pain influences somatosensory perception : an experimental and clinical study

   Author : Ann-Sofie Leffler; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Muscle pain; referred pain; hypoaesthesia; allodynia; musculoskeletal; pain; sensory abnormality; quantitative sensory testing; trapezius myalgia; somatosensory perception; perception thresholds; diffuse noxious inhibitory controls DNIC ; central hyperexcitability; tourniquet test; cold-pressor test.;

   Abstract : The underlying mechanisms maintaining long-term pain localised to musculoskeletal structures and joints are not infrequently unknown. In routine clinical work with such patients insufficient attention has been paid to phenomena indicating altered excitability of the central nervous system (CNS). READ MORE