Search for dissertations about: "chemotherapy toxicity in breast cancer"

Showing result 1 - 5 of 13 swedish dissertations containing the words chemotherapy toxicity in breast cancer.

2. 1. Individually Tailored Toxicity-based Chemotherapy : Studies on Patients with Primary and Metastatic Breast Cancer

   Author : Henrik Lindman; Jonas Bergh; Carl Blomqvist; Peter Nygren; Bo Nordenskjöld; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; breast cancer; tailored chemotherapy; toxicity-based dosing; high-dose therapy; MR imaging; G-CSF; epirubicin; docetaxel; cyclophosphamide; 5-fluorouracil; Onkologi; Oncology; Onkologi;

   Abstract : Standard dosing of chemotherapy based on body surface area (BSA) results in large individual differences in toxicity due to a large inter-patient variability in pharmacokinetics (PK) and pharmacodynamics (PD). This results in under-dosing in certain patients with a potentially weaker antitumoral effect. READ MORE

4. 2. Chemosensitivity in Breast Cancer

   Author : Kenneth Villman; Carl Blomqvist; Ulf Tidefelt; Nils Wilking; Uppsala universitet; []
   Keywords : Oncology; breast cancer; chemotherapy; anthracycline; predictive; topoisomerase; TOP2A; HER2; cyclin A; in vitro; Onkologi;

   Abstract : Breast cancer mortality in Sweden is now in decline, thanks to early detection and the wide use of adjuvant endocrine therapy and chemotherapy. While hormone receptor status is predictive of response to endocrine treatment, there is no clinically useful predictive marker of a patient’s response to chemotherapy. READ MORE

5. 3. Quality of life and psychological reactions in women on first line chemotherapy for metastatic breast cancer - Correlations to tumour response and predictive factors

   Author : Helene Svensson; Göteborgs universitet; []
   Keywords : Breast cancer; Recurrence; Health-related quality of life; EORTC QLQ-C30; Metastatic breast cancer; Prognostic factors; Chemotherapy; Toxicity; SNP; Psychological reactions;

   Abstract : Background: Health-related quality of life (HRQoL) is an important endpoint in clinical trials and as an aspect that must be considered in the treatment of patients with metastatic breast cancer. Treatment efficacy and toxicity are important factors for HRQoL, so it is imperative to study the effects of oncological treatment in terms of HRQoL. READ MORE

6. 4. Anthracyclines : Toxicity and chemotherapy-induced mucositis

   Author : Fredrik Kullenberg; Hans Lennernäs; Erik Sjögren; David Dahlgren; Femke Heindryckx; Henrik Rönnberg; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anthracycline; doxorubicin; idarubicin; toxicity; intracellular concentration; IC50; chemotherapy-induced mucositis; apoptosis; proliferation; permeability; anti-inflammatory drugs; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : Anthracyclines belong to a class of cytostatic compounds that are commonly used to treat various types of cancers, including lymphoma, breast cancer and primary liver cancer. The aim of this thesis was to study how two anthracyclines, doxorubicin and idarubicin, induced cytotoxicity in tumor cells, as well as their off-target effect on the gastrointestinal system. READ MORE

7. 5. Cardiac and pulmonary side-effects of radiotherapy in early breast cancer

   Author : Ulla Blom Goldman; Karolinska Institutet; Karolinska Institutet; []
   Keywords : breast cancer;

   Abstract : The purpose of this thesis was to study early and late side-effects to lung and heart in adjuvant locoregionalradiation therapy (LRRT) of early breast cancer (BC). Papers I-III were intervention studies aiming to reduce symptomatic/ radiological pneumonitis and functional changes after LRRT by applyingthe ipsilateral lung dose volume constraint V20 ≤ 30 %. READ MORE