Search for dissertations about: "chimeric antigen receptor"

Showing result 1 - 5 of 25 swedish dissertations containing the words chimeric antigen receptor.

  2. 1. The Multiple Faces of Genetically-Modified T Cells : Potential Applications in Therapy

    Author : Victoria Hillerdal; Magnus Essand; Johanna Olweus; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer immunotherapy; genetically engineered T cells; chimeric antigen receptor; T cell receptor; antigen-specific T cells; immunotherapy; Immunologi; Immunology; Klinisk immunologi; Clinical Immunology;

    Abstract : In this PhD thesis the potential of T-cells as therapy for disease are explored. The applications of genetically modified T-cells for treatment of cancer and autoimmune disease; the functionality and optimal activation of T-cells are discussed. READ MORE

  4. 2. Modulation of B cell access to antigen by passively administered antibodies : an explanation for antibody feedback regulation?

    Author : Hui Xu; Birgitta Heyman; Helena Harris; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IgG; IgG3; IgE; suppression; enhancement; epitope masking; antigen transport; antigen presentation; follicular B cells; marginal zone B cells; Immunologi; Immunology;

    Abstract : Antibody responses can be up- or down-regulated by passive administration of specific antibody together with antigen. Depending on the structure of the antigen and the antibody isotype, responses can be completely suppressed or enhanced up to a 1000-fold of what is seen in animals immunized with antigen alone. READ MORE

  5. 3. Cancer Immunotherapy : Evolving Oncolytic viruses and CAR T-cells

    Author : Mohanraj Ramachandran; Magnus Essand; Di Yu; Justyna Leja-Jarblad; Richard Vile; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncolytic virus; Adenovirus; Semliki Forest virus; Cancer immunology; Chimeric antigen receptor T-cells; Immunologi; Immunology; Oncology; Onkologi; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Abstract : In the last decade cancer immunotherapy has taken huge strides forward from bench to bedside and being approved as drugs. Cancer immunotherapy harnesses the power of patient’s own immune system to fight cancer. READ MORE

  6. 4. Translational studies of metastatic melanoma in the era of immunotherapy - from humanized mouse models to clinical trials

    Author : Henrik Jespersen; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metastatic melanoma; Uveal melanoma; Humanized mouse models; Immunotherapy; Chimeric antigen receptor T cells; PD-1 inhibition; Epigenetics; Histone deacetylase inhibition;

    Abstract : Immunotherapy with PD-1 inhibitors has transformed the treatment of met-astatic cutaneous mela- noma, and can lead to complete and durable responses in a proportion of patients. However, in around half of the patients, the treatment has little or no effect. READ MORE

  7. 5. NK cell inhibitory receptor interactions with MHC class I molecules

    Author : Jonas Sundbäck; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NK cells; MHC class I molecules; inhibitory receptors;

    Abstract : Natural killer (NK) cells represent the third population of lymphocytes in size after B- and T-cells. NK mediated killing of target cells is strongly influenced by MHC class I molecules expressed on target cells. In contrast to T-cells, NK cells can be inhibited by MHC class I molecules through the action of specific inhibitory NK cell receptors. READ MORE