Search for dissertations about: "chiral electrophoresis"

Showing result 1 - 5 of 15 swedish dissertations containing the words chiral electrophoresis.

  2. 1. Enantiomeric Separations using Chiral Counter-Ions

    Author : Jakob Haglöf; Curt Pettersson; Anders Karlsson; Jacques Crommen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Capillary Electrophoresis; Chiral Counter-Ion; Divalent Dipeptide; Enantioselectivity; Electroosmosis; Chemometrics; Molecular Descriptor; Structure-Enantioselectivity Relationship; Pharmaceutical chemistry; Farmaceutisk kemi; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Abstract : This thesis describes the use of chiral counter-ions for the enantiomeric separation of amines in non-aqueous capillary electrophoresis. The investigations have been concentrated on studies of the influence, of the chiral counter-ion, the solvent, the electrolyte and the analyte, on the enantioselective separation. READ MORE

  4. 2. New Techniques for Chiral Separations

    Author : Jeanette Olsson; Lars Blomberg; Steen Honoré Hansen; Karlstads universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; analytical chemistry; chiral separation; GC; CE; CEC; Analytical chemistry; Analytisk kemi; Kemi; Chemistry;

    Abstract : Gas chromatography (GC) has been utilized for the study of enantiomer resolution of the atropisomers of PCBs, o,p´-DDD and o,p´-DDT. Different substituents and concentrations of cyclodextrin, capillary dimensions and type of stationary phase films have been investigated to achieve the resolution of as many of the atropisomers on one column as possible. READ MORE

  5. 3. Chiral Separation of Amines by Non-Aqueous Capillary Electrophoresis using Low Molecular Weight Selectors

    Author : Ylva Hedeland; Curt Pettersson; Ulf Bondesson; Lars Blomberg; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Pharmaceutical chemistry; Chiral Separation; Non-Aqueous Capillary Electrophoresis; Enantioresolution; Electro-osmotic Flow; Pharmaceuticals; Enantiomeric Amines; Low Molecular Weight Selector; Farmaceutisk kemi; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Abstract : Three chiral selectors (diketogulonic acid, benzoxycarbonylglycylproline and ketopinic acid) have been introduced for enantioseparation of pharmacologically active amines in non-aqueous capillary electrophoresis. The use of organic solvents, instead of aqueous buffers in the background electrolyte facilitated ion-pair formation between the analytes and the chiral selectors. READ MORE

  6. 4. Separation of Pharmaceuticals by Capillary Electrophoresis using Partial Filling and Multiple-injections

    Author : Henrik Lodén; Curt Pettersson; Torbjörn Arvidsson; Ahmad Amini; Morgan Stefansson; Uppsala universitet; []
    Keywords : Capillary Coating; Chiral Separation; Enantiomers; Mass-spectrometric Detection; Method Validation; Multiple-injection Capillary Zone Electrophoresis; Non-aqueous Capillary Electrophoresis; Organic Solvents; Pharmaceutical Analysis; Quantitative Analysis;

    Abstract : Different multiple-injection methodologies and the partial filling technique (PFT) have been utilized for separation of pharmaceuticals by capillary elec-trophoresis. In multiple-injection capillary zone electrophoresis (MICZE), the samples and all standards, used for construction of the calibration curve, are analyzed within a single run. READ MORE

  7. 5. Electrochemical Methods for Drug Characterisation and Transdermal Delivery : Capillary Zone Electrophoresis, Conductometry, and Iontophoresis

    Author : Nadia Merclin; Per Hansson; Sven Engström; Arto Urtti; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Capillary zone electrophoresis; precision conductometry; iontophoresis; passive diffusion; lidocaine; ALA; ALA-ester derivatives; sponge phase; carbopol gel; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Abstract : This thesis concerns the development and utilisation of techniques for characterisation and transdermal delivery of various systems for pharmaceutical applications.The degree of dissociation of drug molecules and the mobilities of the different species formed are essential factors affecting the rate of drug delivery by iontophoresis. READ MORE