Search for dissertations about: "cholerae"

Showing result 1 - 5 of 48 swedish dissertations containing the word cholerae.

2. 1. Modulators of Vibrio cholerae predator interaction and virulence

   Author : Barbro Lindmark; Sun Nyunt Wai; Kristian Riesbeck; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vibrio cholerae; Caenorhabditis elegans; PrtV; outer membrane vesicles; non-O1 non-O139; serum resistance; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

   Abstract : Vibrio cholerae, the causal agent of cholera typically encodes two critical virulence factors: cholera toxin (CT), which is primarily responsible for the diarrhoeal purge, and toxin-co-regulated pilus (TCP), an essential colonisation factor. Nontoxigenic strains expressing TCP can efficiently acquire the CT gene through lysogenic conversion with CTXΦ, a filamentous phage that encodes CT and uses TCP as a receptor. READ MORE

4. 2. Regulatory roles of sRNAs in pathogenesis of Vibrio cholerae

   Author : Dharmesh Sabharwal; Sun Nyunt Wai; Bernt Eric Uhlin; Jörgen Johansson; Cynthia Sharma; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vibrio cholerae; sRNA; Biofilm; OmpT; RbmC; Vrp; VafA; mikrobiologi; Microbiology;

   Abstract : The Gram-negative pathogen Vibrio cholerae uses variety of regulatory molecules to modulate expression of virulence factors. One important regulatory element of microorganisms is small non-coding RNAs (sRNAs), which control various cell functions such as expression of cell membrane proteins, mRNA decay and riboswitches. READ MORE

5. 3. Vibrio cholerae modulates the immune defense of human gut mucosa

   Author : Aziz Bitar; Marie-Louise Hammarström; Sun Nynt Wai; Mikael Rehn; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vibrio cholerae; intestinal epithelial cell; duodenum biopsy; acute cholera; immunomodulation; microRNA; OMV; cytokine; T84 monolayer; miR-146; miR-155; VCC; PrtV; hemolysis; IL-8; TNF-a; IL-1b; IL-18; CCL20; IRAK2; inflammation; mikrobiologi; Microbiology; immunologi; Immunology;

   Abstract : The key function of innate immunity is to sense danger signals and initiate effective responses as a defense mechanism against pathogens. Simultaneously, effector responses must be regulated to avoid excessive inflammation with resulting tissue damage. READ MORE

6. 4. Structural and functional studies of the secreted metalloprotease PrtV from Vibrio cholerae

   Author : Aaron Edwin; Elisabeth Sauer-Eriksson; Helena Berglund; Umeå universitet; []
   Keywords : Cholera; Vibrio cholerae; virulence factors; PrtV; X-ray crystallography; NMR;

   Abstract : Cholera, an acute diarrheal diseases caused by the intestinal infection of the pathogenic bacterium Vibrio cholerae, continues to be a global killer in the world today. PrtV, a secreted zinc metalloprotease, is a potent cytotoxic virulence factor of V. cholerae. READ MORE

7. 5. Effect of virulence factors on survival strategies of vibrio cholerae and vibrio mimicus

   Author : Soni Priya Valeru; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Vibrio cholerae;

   Abstract : Vibrio is a genus of gram-negative bacteria comprising nearly 70 species and they are clinically human pathogens that can cause many infections. This study is mainly based on two species such as Vibrio cholerae O1 El Tor, which cause cholera disease and Vibrio mimicus, that cause gastroenteritis, open wounds infection, and septicemia. READ MORE