Search for dissertations about: "chromosome sequences"

Showing result 1 - 5 of 102 swedish dissertations containing the words chromosome sequences.

2. 1. Evolutionary Studies of the Mammalian Y Chromosome

   Author : Linda Hellborg; Hans Ellegren; Terry Burke; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Y chromosome; field vole; cattle; selection; primer design; Genetik; Clinical genetics; Klinisk genetik;

   Abstract : Sex chromosomes are useful in elucidating the evolutionary factors affecting diversity and divergence. In particular, Y chromosome analyses may complement studies using mitochondrial DNA for inferring sex-specific population genetic processes. READ MORE

4. 2. A Unified Multitude : Experimental Studies of Bacterial Chromosome Organization

   Author : Eva Garmendia; Diarmaid Hughes; Linus Sandegren; John R. Roth; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; bacterial evolution; chromosome organization and structure; chromosomal inversions; EF-Tu; horizontal gene transfer; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

   Abstract : Bacteria are many, old and varied; different bacterial species have been evolving for millions of years and show many disparate life-styles and types of metabolism. Nevertheless, some of the characteristics regarding how bacteria organize their chromosomes are relatively conserved, suggesting that they might be both ancient and important, and that selective pressures inhibit their modification. READ MORE

5. 3. Chromosomal Instability and Genomic Amplification in Bone and Soft Tissue Tumours

   Author : David Gisselsson Nord; Avdelningen för klinisk genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nuclear atypia; kinetochore; anaphase bridge; p53; breakage-fusion-bridge cycle; TP53; HMGIC; MDM2; mitotic instability; genomic instability; FISH; osteosarcoma; liposarcoma; amplification; tumour; chromosome; cytogenetics; Clinical genetics; Klinisk genetik;

   Abstract : Acquired genetic abnormalities are found in all types of malignant tumours and may contribute to neoplastic processes by altering protein structure or dosage. Many bone and soft tissue tumours (BSTT) are characterised by complex patterns of chromosome changes, including extensive intratumour heterogeneity and amplification of DNA sequences. READ MORE

6. 4. Evolutionary History of the Root Vole (Microtus oeconomus) as Revealed by Y Chromosome and Mitochondrial DNA sequences

   Author : Cecilia Brunhoff; Malmö Patologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Genetics; colonization history; phylogeography; root vole; cytogenetics; Genetik; cytogenetik;

   Abstract : The root vole (Microtus oeconomus) is a rodent with Holarctic distribution. In fact, it is the only Microtus vole found in both Eurasia and North America. Phylogeographic analyses of the root vole from across its distribution range were performed using mitochondrial and Y chromosome DNA sequences. READ MORE

7. 5. Genetic and epigenetic characterization of pediatric high hyperdiploid acute lymphoblastic leukemia

   Author : Josef Davidsson; Avdelningen för klinisk genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; high hyperdiploid ALL; children; chromosome aberration; methylation profiling; array CGH; relapse; SNP array; clonal relationship; dup 1q ;

   Abstract : The aim of this thesis was to analyze the genetic and epigenetic characteristics of pediatric high hyperdiploid acute lymphoblastic leukemia (HeH ALL), the most common type of childhood malignancy. The three original articles presented in this thesis have addressed three major questions regarding HeH ALL: what are the genetic characteristics of the most common structural abnormality – dup(1q)? Are aberrant methylation patterns involved in leukemogenesis? How do diagnostic and relapse samples relate to each other genetically? In article I we found that the proximal breakpoints of dup(1q)-positive Burkitt lymphomas (BL) and pediatric HeH ALLs cluster close to the centromere, suggesting this region to be breakprone, and that five genes on 1q were significantly overexpressed and thus potentially pathogenetically important. READ MORE