Search for dissertations about: "clinical relevance"

Showing result 1 - 5 of 431 swedish dissertations containing the words clinical relevance.

  2. 1. Gastroenteropancreatic Neuroendocrine Neoplasms Grade 3 : Biological and Clinical Aspects

    Author : Abir Salwa Ali; Malin Grönberg; Christoffer Juhlin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The aim of this thesis was to investigate biological and clinical aspects of G3 gastroenteropancreatic neuroendocrine neoplasms (G3 GEP-NENs).In our first study, the expression of the tumor suppressor p53 was investigated. In a cohort of G3 GEP-NENs we found the expression of p53 protein to be present in 39% of 124 cases. READ MORE

  4. 2. Spatial immune analyses in clinical cancer tissue

    Author : Max Backman; Patrick Micke; Fredrik Pontén; Johan Botling; Kurt Schalper; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immune landscape; non-small cell lung cancer; immune cells; multiplex immunofluorescence; spatial analysis; Medicinsk vetenskap; Medical Science;

    Abstract : Cancer is a leading cause of premature death and lung cancer is the deadliest cancer type, with non-small cell lung cancer (NSCLC) representing 85% of lung cancer cases. Despite promising development in cancer treatment in recent decades, overall prognosis is poor. READ MORE

  5. 3. Clinical Pharmacogenetics of Olanzapine : with Focus on FMO Gene Polymorphisms

    Author : Mao Mao Söderberg; Marja-Liisa Dahl; Maria Gabriella Scordo; Inger Johansson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; olanzapine; pharmacogenetics; drug metabolism; schizophrenia; therapeutic drug monitoring; FMO1; FMO3; CYP1A2; UGT1A4; Clinical Pharmacology; Klinisk farmakologi;

    Abstract : Pharmacogenetics is the study of variability in drug response attributed to genetic variation. Olanzapine (OLA) is a widely used antipsychotic drug for schizophrenia treatment. The pharmacokinetics of OLA display large inter-individual variation leading to multiple-fold differences in drug exposure between patients at a given dose. READ MORE

  6. 4. SCHIZOPHRENIA IN A LONGITUDINAL PERSPECTIVE clinical and neurocognitive aspects

    Author : Jonas Eberhard; Lund Psykiatri; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; toxikologi; farmaci; farmakognosi; toxicology; Farmakologi; pharmacognosy; pharmacy; Pharmacological sciences; Folkhälsa; epidemiologi; epidemiology; Public health; psykosomatik; klinisk psykologi; Psykiatri; psychosomatics; clinical psychology; Psychiatry; longitudinal; shared decision making; schizophrenia; cognition; prolactin; tardive dyskinesia; remission; Medicine human and vertebrates ; insight; Medicin människa och djur ; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Abstract : Objective: To explore the long-term course and to study factors of potential relevance for the treatment and rehabilitation process of patients with schizophrenia and schizophrenia-like disorders. Specific issues concerned cognitive reduction, tardive dyskinesia (TD), prolactin-induced side effects, remission and lack of insight. READ MORE

  7. 5. Clinical relevance of high-sensitive Troponin T in cardiovascular disease

    Author : Christian Bjurman; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biomarkers; prognostic score; mortality; heart failure; myocardial infarction; renal dysfunction;

    Abstract : Background and aims: Troponin T (hs-cTnT) is a cardiac damage marker used in the diagnosis of non-ST segment elevation myocardial infarction (NSTEMI) and for prognostic assessment. Clinical decision-making should ideally be based on evidence. READ MORE