Search for dissertations about: "clinical research"
Showing result 1 - 5 of 3464 swedish dissertations containing the words clinical research.
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1. Preclinical tumor-immune modeling : For the identification of immunomodulatory drugs
Abstract : For a long time, the field of cancer research was dominated by a tumor cell-centric view. That, however, changed once it became recognized that medical cancer treatment is largely influenced by the combined effect exerted on both cancer and immune cells. READ MORE
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2. Tendinosis in Trigger Finger
Abstract : Trigger finger is one of the most common hand conditions, with a prevalence of almost 3%. The aetiology remains unclear even though many causes have been suggested. The prevailing paradigm is that the pathogenesis of trigger finger is ascribed to primary changes in the first fibrous condensation of the tendon sheath (A1-pulley). READ MORE
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3. Mapping the Huntington's disease process using cerebrospinal fluid analysis
Abstract : Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, caused by a CAG-repeat expansion in the HTT-gene. Today there are no disease-modifying therapies (DMTs), but several promising clinical trials are underway, including therapies that reduce mutant huntingtin expression. READ MORE
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4. SOD1 misfolding and aggregation in ALS : in the light of conformation-specific antibodies
Abstract : Mutations in the superoxide dismutase 1 (SOD1) gene are linked to the progressive neurodegenerative disease amyotrophic lateral sclerosis (ALS). ALS-associated mutations affect the stability of the SOD1 protein and promote its unfolding. As a consequence, disordered SOD1 species can misfold and accumulate into insoluble aggregates. READ MORE
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5. Insulin Resistance : Causes, biomarkers and consequences
Abstract : The worldwide increasing number of persons affected by largely preventable diseases like diabetes demands better prevention and treatment. Insulin is required for effective utilisation of circulating nutrients. READ MORE
