Search for dissertations about: "colon targeted"

Showing result 1 - 5 of 25 swedish dissertations containing the words colon targeted.

  2. 1. Regulatory T cells and mucosal-associated invariant T cells in colon adenocarcinomas; Phenotype and function

    Author : Filip Ahlmanner; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colon cancer; regulatory T cells; CD39; adenosine; immune checkpoint molecules; immunosuppression; MAIT cells; cytokines; cancer-specific survival;

    Abstract : In many solid cancers, and also in colon adenocarcinomas, an increased accumulation of lymphocytes is beneficial for the patient. However, tumor-infiltrating immune cells may be either pro- or anti-tumorigenic and the balance between these two counteracting forces partly determines patient outcome. READ MORE

  4. 2. Pharmacokinetic aspects of drugs targeted for the colon, with special reference to olsalazine

    Author : E. Märta Ryde; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  5. 3. T cells in colon cancer; migration and effector functions

    Author : Louis Szeponik; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Treg; CRC; TIL; nSMase2; Transendothelial migration; Unconventional T cells;

    Abstract : Immune cells are recognised as one of the main players in the tumor microenvironment and targeted by many new cancer therapies. Regulatory T cells (Treg) can suppress tumor infiltrating lymphocytes which are associated with a better patient outcome. READ MORE

  6. 4. Cellular targets of HAMLET, their role in tumor cell death and therapeutic potential

    Author : Aftab Nadeem; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer therapy; colon cancer; bladder cancer; cell death; HAMLET; alpha-lactalbumin; oleate; membrane lipids; nucleotide-binding protein; Ras GTPases; alpha-helical peptides;

    Abstract : Protein-lipid complexes have broad and specific effects against cancers of different origins. HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a complex of partially unfolded α-lactalbumin and oleic acid that kills a wide range of tumor cells but leaves healthy differentiated cells unaffected. READ MORE

  7. 5. Role and mechanism of estrogen receptor beta in the ovary and colon

    Author : Madeleine Birgersson; Cecilia Williams; Amena Archer; Claudia Kutter; Eduardo Villablanca; David Moore; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicinsk teknologi; Medical Technology;

    Abstract : Estrogen regulates a variety of important physiological functions in both males and females, where the regulation of female reproduction and the development of sexual organs are typical examples. The effects of estrogen are predominantly exerted via signaling through the two nuclear receptors estrogen receptor α (ERα) and β (ERβ), or the membrane G protein-coupled estrogen receptor 1 (GPER1). READ MORE