Search for dissertations about: "colony-stimulating factor"

Showing result 1 - 5 of 54 swedish dissertations containing the words colony-stimulating factor.

2. 1. RUNX1/AML1 functions and mechanisms regulating granulocyte-macrophage colony-stimulating factor transcription

   Author : Hebin Liu; Sven Påhlman; Umeå universitet; []
   Keywords : RUNX1 AML1; Granulocyte-macrophage colony-stimulating factor GM-CSF ; Calcineurin; CaMKII; Ets1; Transforming growth factor-b TGF-b ; Smad3; molekylärbiologi; Molecular Biology;

   Abstract : Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multipotent cytokine involved in the production and function of hematopoietic cells, and GM-CSF plays in particular a major role in responses to infection and physiological and pathological inflammatory processes. GM-CSF is produced in many cell types, and increases in the intracellular Ca2+ concentration are, like in many other systems, of major importance in the intracellular signaling that determines GM-CSF expression after receptor stimulation of the cells. READ MORE

4. 2. Repair and Reconstruction of Peripheral Nerve Injuries. Treatment with G-CSF and Stromal Vascular Fraction

   Author : Hanna Frost; Malmö Handkirurgi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peripheral nerve injuries; nerve regeneration; reconstructive surgical procedures; diabetes mellitus; rat sciatic nerve; granulocyte colony-stimulating factor; stromal vascular fraction; electrospinning; rats; Schwann cells;

   Abstract : While surgery is a cornerstone in treatment of peripheral nerve injuries, it is not a comprehensive approach, and outcome is unsatisfactory, especially sensory function. The present aim was to translate recent findings about stem- and progenitor cells to improve regenerative outcome, where the cells have to be autologous, available within the same surgical procedure, and minimally manipulated. READ MORE

5. 3. Transforming growth factor a in human hematopoietic cells

   Author : Thomas M. Walz; Linköpings universitet; []
   Keywords : MEDICINE; MEDICIN;

   Abstract : TGF-a, transforming growth factor a, is a potent growth factor belonging to the family of EGF (epidermal growth factor) -related proteins. Binding to the same receptor as EGF it has a ubiquitous repertoire of target cells, including, mesenchymal, epithelial and neuronal cells. READ MORE

6. 4. Cervical ripening : an inflammatory process involving cytokines, metalloproteinases and foetal fibronectin

   Author : Maria Sennström; Karolinska Institutet; Karolinska Institutet; []
   Keywords : cervical ripening; interleukin-8; interleukin-6; granulocyte colony stimulating factor; metalloproteinase- 1; -3 - and -8; foetal fibronectin;

   Abstract : The aim of the thesis was to identify cytokines, metalloproteinases and foetal fibronectin in human cervical tissue and to investigate if changes are of importance for the final cervical ripening. The human cervical ripening is a prerequisite for a normal start and progress of labour. READ MORE

7. 5. Kostmann syndrome : a clinical and pathophysiological study

   Author : Göran Carlsson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Kostmann syndrome; severe congenital neutropenia; autosomal recessive; periodontitis; antibacterial peptides; LL-3 7; apoptosis; Bcl-2; granulocyte colony-stimulating factor; glycosylation; lenograstim; filgrastim.;

   Abstract : Kostmann syndrome or severe congenital neutropenia (SCN) is a rare disease, usually diagnosed during the first months of life, characterized by extremely low levels of neutrophils in the peripheral blood, a maturational arrest of the myelopoiesis in the bone marrow and severe bacterial infections. The purpose of this project was to improve the understanding of the clinical course and the pathophysiology of autosomal recessive SCN. READ MORE