Search for dissertations about: "combination therapies"

Showing result 1 - 5 of 170 swedish dissertations containing the words combination therapies.

  2. 1. Nonlinear Mixed Effects Modeling of Combination Therapies in Oncology

    Author : Marcus Baaz; Stiftelsen Fraunhofer-Chalmers Centrum för Industrimatematik (FCC); []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacol- ogy; Radiation Therapy; Oncology; Mathematical Modeling; Combination Therapy; Nonlinear Mixed Effects;

    Abstract : It has been shown that simultaneous administration of two or more anticancer agents can have a beneficial effect on cancer patients. This type of treatment is called combination therapy and is nowadays commonly used in the fight against cancer. READ MORE

  4. 2. Immunological Checkpoint Blockade and TLR Stimulation for Improved Cancer Therapy

    Author : Sara Mangsbo; Thomas Tötterman; Angelica Loskog; Rolf Kiessling; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CpG ODNs; TLR-9; CTLA-4; PD-1; PD-L1; B7. H1; immunotherapy; checkpoint blockade; bladder cancer; cancer; complement; TLRs; Compstatin; properdin; C3; experimental animal model; whole blood loop system; combination therapies; Clinical immunology; Klinisk immunologi; Tumour immunology; Tumörimmunologi; immunologi; Immunology;

    Abstract : This thesis concerns the investigation of novel immunotherapies for cancer eradication. CpG therapy was used in order to target antigen-presenting cells (APCs), facilitating antigen presentation and activation of T cells. READ MORE

  5. 3. Modeling of combination therapy to support drug discovery in oncology

    Author : Tim Cardilin; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Pharmacokinetics Pharmacodynamics; Oncology; Nonlinear Mixed-Effects Models; Model-Based Drug Development; Combination Therapy;

    Abstract : Mathematical models based on ordinary differential equations, with impulses, are used to describe tumor growth after different treatment combinations, including chemicals as well as radiation. The models are calibrated, using a nonlinear mixed-effects framework, based on time series data of tumor volume from animal experiments. READ MORE

  6. 4. Experimental therapies of malignant glioma : with emphasis on angiogenesis inhibition

    Author : Maria Sandström; Roger Henriksson; Mikael Johansson; Anja Smits; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; angiogenesis; VEGF; tyrosinekinaseinhibitor; ZD6474; plasminogenactivator; tPA; uPA; proteomics; Oncology; Onkologi;

    Abstract : Malignant glioma consists of a group of diseases where the localisation and the nature of the disease makes treatment an extreme challenge. Two important biological features of malignant glioma cells are their infiltrative growth and their ability to induce angiogenesis. READ MORE

  7. 5. Combination Therapies Targeting PDGF and VEGF Signaling Pathways in Solid Tumors

    Author : Agnieszka Kłosowska-Wardęga; Carina Hellberg; Carl-Henrik Heldin; Per Lindahl; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN; Oncology; Onkologi;

    Abstract : Vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) are independently involved in several cancer-associated mechanisms including autocrine stimulation of cancer cells, stimulation of tumor angiogenesis and regulation of interstitial fluid pressure (IFP). The scope of this thesis was to investigate the combinatory effect of anti-VEGF and anti-PDGF treatment on tumor angiogenesis and tumor IFP. READ MORE