Search for dissertations about: "complement factor C4."

Showing result 1 - 5 of 13 swedish dissertations containing the words complement factor C4..

  2. 1. Crosstalk Between Activated Platelets and the Complement System

    Author : Osama A. Hamad; Bo Nilsson; Kristina Ekdahl-Nilsson; Lennart Truedsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; platelets; activated platelets; TRAP; chondroitin sulfate; C1q; factor H; C4BP; C3; Compstatin; complement; platelet-leukocyte complexes; platelet microparticles; Clinical immunology; Klinisk immunologi; Klinisk immunologi; Clinical Immunology;

    Abstract : Several studies have shown that complement and thrombotic events co-exist. Platelets have been suspected to act as the bridge between the two cascade systems. READ MORE

  4. 2. Genetic, molecular and functional analyses of factor I - an inhibitor of the complement system

    Author : Sara Nilsson; Malmö Proteinkemi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; atypical hemolytic uremic syndrome; deficiency; Complement inhibition; factor I; renal disease;

    Abstract : Factor I (FI) is a serine protease that inhibits the complement system by cleaving activated C3 and C4 complement proteins, in the presence of cofactors. Mutations in the gene coding for FI have been identified in complete FI deficient- and atypical hemolytic uremic syndrome (aHUS) patients. READ MORE

  5. 3. Synaptic elimination and the complement system in Alzhaimer's disease

    Author : Jonny Daborg; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Synapse; Alzheimer s disease; Genetics; CSF; Complement; RAGE;

    Abstract : The mechanisms behind Alzheimer’s disease (AD) are largely unknown. The disease is to a large extent hereditary, and the best pathophysiological correlate to the severity of the symptoms is loss of synapses. READ MORE

  6. 4. Interactions between platelets and complement with implications for the regulation at surfaces

    Author : Per H. Nilsson; Kristina Nilsson Ekdahl; John Lambris; Ian Nicholls; Berhane Ghebrehiwet; Linnéuniversitetet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; complement system activation; regulation ; platelets activation; regulation ; biomaterials; biocompatibility; chondroitin sulfate-A; apyrase; C1q; C3; factor H; C4BP; ADP; Biomedical Sciences; Biomedicinsk vetenskap;

    Abstract : Disturbances of host integrity have the potential to evoke activation of innate immunologic and hemostatic protection mechanisms in blood. Irrespective of whether the activating stimulus is typically immunogenic or thrombotic, it will generally affect both the complement system and platelets to a certain degree. READ MORE

  7. 5. Clinical, epidemiological and immunological aspects of Lyme borreliosis with special focus on the role of the complement system

    Author : Anna J Henningsson; Jan Ernerudh; Pia Forsberg; Kristina Nilsson Ekdahl; Bo-Eric Malmvall; Lars Hagberg; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lyme borreliosis; neuroborreliosis; clinical; epidemiology; inflammation; complement; cytokine; chemokine;

    Abstract : Lyme borreliosis (LB) is the most common vector-borne disease in the Northern Hemisphere. The infection is caused by spirochetes belonging to the Borrelia burgdorferi sensu lato complex, and it is transmitted to humans by ticks. READ MORE