Search for dissertations about: "compressed tablets"

Found 5 swedish dissertations containing the words compressed tablets.

  2. 1. Pharmaceutical binders and their function in directly compressed tablets : Mechanistic studies on the effect of dry binders on mechanical strength, pore structure and disintegration of tablets

    Author : Sofia Mattsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; Compaction; tablet; binder; pore structure; disintegration; FARMACI; PHARMACY; FARMACI; farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Abstract : In this thesis, the strength-enhancing mechanisms of dry binders in direct compression were studied. The systems investigated were binary mixtures containing various compounds and binders. Among the binders used were a series of different molecular weights of polyethylene glycol. READ MORE

  4. 2. Investigation of the functionality related characteristics of hydroxypropyl methylcellulose for the release from matrix tablets

    Author : Anna Viridén; Chalmers tekniska högskola; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; functionality related characteristics; batch-to-batch variation; hydrophilic matrix tablets; hydroxypropyl methylcellulose; polymer characterisation; heterogeneous; drug release;

    Abstract : Hydrophilic matrix tablets are a compressed well mixed composite of drug substance and excipients including a hydrophilic polymer. When the tablet comes in contact with biological fluids, the hydrophilic polymer starts to dissolve, a process that decreases the water penetration through the tablet and involves dimensional changes of the tablet due to swelling of the solvated polymers. READ MORE

  5. 3. Compression mechanics of pharmaceutical aggregates : Studies on the tabletting of spheronised aggregates with varying composition and porosity

    Author : Fredrik Nicklasson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

    Abstract : The thesis investigated the tabletting behaviour of aggregates of different porosity and material composition, and focused on the role of the compression mechanics of the aggregates as a link between their structure and composition and the structure and functionality of tabletsformed from them. The aggregates studied all responded to compression by deformation and densification. READ MORE

  6. 4. Novel and refined small-scale approaches to determine the intrinsic dissolution rate of drugs

    Author : Sara B. E. Andersson; Göran Alderborn; Göran Frenning; Peter Langguth; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dissolution; intrinsic dissolution rate; poorly water-soluble compounds; single particle dissolution; solubility; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Many drugs are administered as crystalline particles compressed into tablets and taken orally. When the tablet reaches the gastrointestinal tract, it disintegrates and the drug particles dissolve in the gastrointestinal fluid. The dissolved molecules are absorbed across the intestinal membranes into the bloodstream to reach their target sites. READ MORE

  7. 5. Pharmaceutical and Biomedical Applications of Spectroscopy in the Photon Migration Regime

    Author : Tomas Svensson; Atomfysik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Porosimetry; Biomedical optics; Pharmaceutical analysis; Monte Carlo; Scattering media; Photon migration; Laser spectroscopy; High-resolution spectroscopy; Time-resolved spectroscopy; Time-of-flight;

    Abstract : The present thesis is devoted to two different matters: One part is the development of a novel optical technique for characterisation of solid pharmaceutical materials. The other part being the continued development of photon time-of-flight spectroscopy, as well as exploration of new application areas of this method. READ MORE