Advanced search

Showing result 1 - 5 of 38 swedish dissertations matching the above criteria.

2. 1. Inhibitors Targeting Insulin-Regulated Aminopeptidase (IRAP) : Identification, Synthesis and Evaluation

   Author : Karin Engen; Mats Larhed; Mikael Elofsson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; compound screening; insulin-regulated aminopeptidase; IRAP; inhibitors; cognitive disorders; spiro-oxindole; quinazolinone; imidazopyridine; medicinal chemistry; structure-activity relationship; microwave heating; Medicinal Chemistry; Läkemedelskemi;

   Abstract : Insulin-regulated aminopeptidase (IRAP) has emerged as a potential new therapeutic target for treatment of cognitive disorders. Inhibition of the enzymatic activity facilitates cognition in rodents. READ MORE

4. 2. Tertiary Alcohol- or β-Hydroxy γ-Lactam-Based HIV-1 Protease Inhibitors : Microwave Applications in Batch and Continuous Flow Organic Synthesis

   Author : Per Öhrngren; Mats Larhed; Knud J. Jensen; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; HIV; AIDS; protease inhibitor; aspartic protease; lactam; tertiary alcohol; continuous-flow; microwave; non-resonant; MAOS; Medicinal Chemistry; Läkemedelskemi;

   Abstract : Since the outbreak of the HIV/AIDS pandemic in the 1980s, the disease has cost the lives of over 30 million people, and a further 33 million are currently living with the HIV infection. With the appropriate treatment, HIV/AIDS can today be regarded as a chronic but manageable disease. READ MORE

5. 3. Together towards safer medication treatment for older persons

   Author : Malin Holmqvist; Linda Johansson; Axel Ros; Johan Thor; Karin Aase; Jönköping University; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; case study; co-design; co-production; feasibility study; medications; nurses; older persons; patient safety; physicians; primary care; qualitative research methods;

   Abstract : This thesis focuses on promoting patient safety in older persons using medications. Given that medications can unintentionally harm patients, the World Health Organisation emphasises “Medication without harm” as a global patient safety challenge. READ MORE

6. 4. Monitoring of Splanchnic Regional Perfusion : An Experimental Study of New Application and Validation

   Author : Itaru Koga; Lennart Christiansson; Lars Wiklund; Björn Biber; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaesthesiology and intensive care; Splanchnic circulation; Regional ischemia; Hepatic artery buffer response; Air tonometry; Intraperitoneal; Reflectance pulse oximetry; Hepatic venous oxygen saturation; Lactate; PCO2 gap; Anestesiologi och intensivvård; Anaesthetics and intensive care; Anestesiologi och intensivvård;

   Abstract : Systemic infection, major surgery, trauma and many other causes can lead to impaired organ function. Compensated shock is not detected by global hemodynamic and oxygen measurements, as they take no account for regional variations. READ MORE

7. 5. Evaluation and revision of performance measurement systems

   Author : Stefan Tangen; Mats Björkman; KTH; []
   Keywords : Technology; performance measurement; performance measurement systems; productivity; evaluation; TEKNIKVETENSKAP; TECHNOLOGY; TEKNIKVETENSKAP;

   Abstract : Performance measurement is a topic that has received considerable attention during the last decades. There are many motives for using performance measures in a company but perhaps the most crucial one is that they will help to improve productivity when used properly. READ MORE