Search for dissertations about: "coreceptor"
Showing result 1 - 5 of 35 swedish dissertations containing the word coreceptor.
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1. Evolution of HIV-1 coreceptor use in relation to pathogenesis
Abstract : HIV-1 uses the coreceptors CCR5 and/or CXCR4 in addition to CD4 to enter the host cell. CCR5-using HIV-1 (R5 phenotype) appears to transmit infection and usually dominates the early stages of disease. READ MORE
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2. Intrapatient evolution of HIV-1 in the context of coreceptor usage
Abstract : The variable region 1 to 3 (V1-V3) of the HIV-1 envelope plays an important role in coreceptor usage. Early in infection HIV- 1 is using CCR5 as coreceptor to enter target cells (R5 viruses) whereas viruses using CXCR4 as coreceptor (X4 viruses) may appear later in infection. READ MORE
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3. Recombinant CXCR4/CCR5 hybrid receptors as tools for studies of HIV-1 receptor usage
Abstract : The chemokine receptors CCR5 and CXCR4 are required, together with CD4, for the entry of HIV-1 into target cells. CCR5 using HIV-1 dominates during transmission and the asymptomatic phase of infection. During progression, virus phenotypes with the ability to use CXCR4 emerge in about 50% of infected individuals. READ MORE
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4. Virus tropism and neutralization response in SIV infection
Abstract : Simian immunodeficiency virus (SIV) infections in macaques are commonly used as models to study the pathogenesis of human immunodeficiency virus (HIV). Both SIV and HIV normally use the CD4 receptor and an additional coreceptor for cell entry. The most common coreceptors used by HIV are CCR5 and CXCR4. READ MORE
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5. HIV-1 evolution, disease progression and molecular epidemiology of HIV-1 single and HIV-1 and HIV-2 dual-infected individuals in Guinea-Bissau
Abstract : The two genetically related human lentiviruses known today, HIV-1 (which is pandemic) and HIV-2 (which mainly is confined to West Africa), are the causative agents of AIDS. Progressive immune dysfunction and AIDS develop in most cases of untreated HIV-1 infection, but only in approximately 25-30% of HIV-2 infected individuals. READ MORE