Search for dissertations about: "coregulator"

Showing result 1 - 5 of 11 swedish dissertations containing the word coregulator.

  2. 1. Gene regulation mechanisms by the transcriptional coregulator mastermind-like 1

    Author : Mariana Saint Just Ribeiro; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Acetylation autoacetylation; chromatin; trnascription; coregulator; Mastermind-like 1 MAML1 ; p300; Notch signaling; phosphorylation; GSK3beta;

    Abstract : MAML1 was first identified as a coactivator for Notch receptors, but later it was also found to function as a coactivator for several other activators, including p53, beta-catenin, and MEF2C. MAML1 is critical for Notch signalling and has been shown to act cooperatively with the histone acetyltransferase (HAT) p300 in transcription that is mediated by the Notch intracellular domain (Notch IC). READ MORE

  4. 2. Transcriptional regulation by the nuclear receptors steroidogenic factor-1 and liver receptor homologue-1

    Author : Anna Ehrlund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Steroidogenic Factor-1 (SF-1) and Liver Receptor Homologue-1 (LRH-1) are transcription factors belonging to the nuclear receptor (NR) family. In the adrenal cortex and gonads, SF-1 governs the expression of multiple enzymes and transporters required for converting cholesterol to steroid hormones. READ MORE

  5. 3. Molecular basis of estrogen receptor antagonism

    Author : Nina Heldring; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Estrogen Receptor; antagonism; receptor signaling; phytoestrogen and conformational changes;

    Abstract : Estrogen Receptors (ERs), ERα and ERβ, are responsible for mediating the physiological effects of the steroid hormone 17b-estradiol and structurally related compounds. ER signaling is a complex process where the combined effects of accessory proteins, known as coregulators, promoter characteristics and influence from other signaling systems, determine the cell-specific transcriptional response in a given situation. READ MORE

  6. 4. Transcription factor control in neuronal maintenance and survival

    Author : Banafsheh Kadkhodaei; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The Transcription factor (TF) Nurr1 is essential for the development of a group of dopamine neurons that are located in the ventral midbrain (also referred to as mesencephalon). A progressive pathology of these midbrain dopamine (mDA) neurons is evident in Parkinson s disease, the most frequent neurodegenerative movement disorder. READ MORE

  7. 5. Modulation of nuclear receptor signaling by RBR ubiquitin ligases

    Author : Nina Gustafsson Sheppard; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nuclear receptors (NRs) constitute a superfamily of transcription factors and play important roles in physiology. Transcriptional regulation by NRs can be modulated through interactions with various coregulators that activate or repress transcription through mediating receptor and chromatin modifications as well as communicating with the general transcription factor machinery. READ MORE