Search for dissertations about: "coupled calculations"

Showing result 1 - 5 of 122 swedish dissertations containing the words coupled calculations.

  2. 1. Development and Applications of a General Coupled Thermal-hydraulic/Neutronic Model for the

    Author : Mathias Stålek; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; reactor transients; measurements; thermal-hydraulics; core calculations; coupled calculations;

    Abstract : Coupled calculations are important for the simulation of nuclear power plants when there is a strongfeedback between the neutron kineticsand the thermal-hydraulics. A general coupled model of the Ringhals-3 Pressurized Water Reactor has beendeveloped for this purpose. READ MORE

  4. 2. Free energy calculations of G protein-coupled receptor modulation : New methods and applications

    Author : Willem Jespers; Hugo Gutiérrez-de-Terán; Johan Åqvist; Jonathan Essex; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; G protein-coupled receptor; adenosine receptor; molecular dynamics; free energy perturbation; homology modeling; computer simulations; conformational selectivity; binding free energy.; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Abstract : G protein-coupled receptors (GPCRs) are membrane proteins that transduce the signals of extracellular ligands, such as hormones, neurotransmitters and metabolites, through an intracellular response via G proteins. They are abundant in human physiology and approximately 34% of the marketed drugs target a GPCR. READ MORE

  5. 3. Development of fine-mesh methodologies for coupled calculations in Light Water Reactors

    Author : Klas Jareteg; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; CFD; Coupled neutronics thermal-hydraulics; nuclear reactor multiphysics; multiphase flow;

    Abstract : This thesis presents fine-mesh multiphysics methodologies and algorithms for numerical predictions of the behavior of Light Water Reactor (LWR) cores. The multiphysics aspects cover the distribution of neutrons, the fluid flow of the coolant and the conjugate heat transfer between the solid fuel pins and the fluid coolant. READ MORE

  6. 4. Development of an integrated neutronic/thermal-hydraulic tool for estimating fluctuations in PWRs

    Author : Viktor Larsson; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Diffusion theory; Fluctuations; Neutron noise; Coupled calculations; P1 theory Analytical Nodal Method;

    Abstract : Monitoring and diagnostics of a reactor core at a given state is very important for detecting potential problems and anomalies at an early stage. Several methods exist for these purposes, but the majority of them require a disruption of the plant operation, e.g. by shut-down or by perturbation of the system. READ MORE

  7. 5. Molecular simulations of G protein-coupled receptors : A journey into structure-based ligand design and receptor function

    Author : Pierre Matricon; Jens Carlsson; Bjørn Olav Brandsdal; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; G Protein-Coupled Receptor; Molecular Dynamics Simulations; Free Energy Perturbation; Ligand Binding; Fragment-Based Lead Discovery; Molecular Docking Screens; Homology Modeling; GPCR Activation Mechanism; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Abstract : The superfamily of G protein-coupled receptors (GPCRs) contains a large number of important drug targets. These cell surface receptors recognize extracellular signaling molecules, which stimulates intracellular pathways that play major roles in human physiology. READ MORE