Search for dissertations about: "cyclin A1"

Found 5 swedish dissertations containing the words cyclin A1.

  2. 1. Cyclin A1 Expression and Regulation in Hematopoietic and Leukemic Cells

    Author : Jenny Ekberg; Malmö Patologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; General pathology; pathological anatomy; Patologi allmän ; patologisk anatomi; onkologi; Cytologi; cancerology; oncology; Cytology; AML; cyclin A1; apoptosis; cell cycle regulation;

    Abstract : Increased expression of the cell cycle regulatory protein cyclin A1 has previously been detected in patients with acute myeloid leukemia (AML) and targeted overexpression of cyclin A1 in a transgenic mouse model initiated AML. The aim of this thesis was to further study the expression and regulation of cyclin A1 in hematopoietic cells. READ MORE

  4. 2. Regulation of normal and cancer cells as a base for cell cycle-targeted therapy

    Author : Regina Miftakhova; Malmö Experimentell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell cycle regulation; cyclin A1; stem cells; stem cell niche; epigenetics; cancer;

    Abstract : The majority of current treatments used for treatment of prostate cancer (PCa) and leukemia are often limited to a narrow subsets of treated patients. As such, there still remains a significant scope for gaining deeper understanding of molecular mechanisms underlying cancer metastasis for improvement of targeted treatment. READ MORE

  5. 3. Response mechanisms of normal hematopoietic cells and leukemic cells to genotoxic agents and novel therapeutic strategies

    Author : Andreas Hedblom; Malmö Experimentell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic stem cells; genotoxic damage; cell cycle; leukemia; heme oxygenase; differentiation;

    Abstract : Hematopoiesis is initiated by a rare population of hematopoietic stem cells (HSC) in the bone marrow (BM). HSCs give rise to red blood cells and white blood cells of myeloid and lymphoid lineages. READ MORE

  6. 4. Targeted therapeutic strategies for prostate cancer treatment using novel lipid kinase inhibitors in combination with current drugs

    Author : Julius Semenas; Jenny L. Persson; Anna Berghard; Maria Fällman; Thomas Grundström; Lukas Kenner; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; bone metastasis; castration-resistant; treatment; precision therapy; PIP5K1A; steroid hormone receptors; cancer stem cells; Oncology; onkologi;

    Abstract : Prostate cancer (PCa) is one of the most common cancer types and the fifth cancer-related cause of death among Western world men.  The sex steroid hormone, androgen and androgen receptor (AR) play important roles in PCa progression. READ MORE

  7. 5. Proteomics of invasiveness of human breast epithelial cells

    Author : Kah Wai Lin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mechanisms of malignant transformation and cancer invasion and factors controlling them in response to various stimuli remain elusive. We used proteomics and systems biology to explore these mechanisms in human breast epithelial cells. The objective has been to identify a set of biomarkers for diagnostics and prognostics of breast cancer. READ MORE