Search for dissertations about: "cyclins"

Showing result 1 - 5 of 26 swedish dissertations containing the word cyclins.

  2. 1. Characterization of Male Breast Cancer : From Molecule to Clinical Outcome

    Author : Cecilia Nilsson; Marie-Louise Fjällskog; Leif Bergkvist; Thomas Hatschek; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; male breast cancer; immunohistochemistry; prognostic; cyclins; gene expression; genomic profiling; Oncology; Onkologi; Oncology; Onkologi;

    Abstract : The aim of this thesis was to investigate different aspects of male breast cancer (MBC), and to compare these with findings in female breast cancer (FBC). In paper I, a population–based study was performed to investigate possible differences in treatment and outcome between MBC and FBC patients. READ MORE

  4. 2. Cyclins on the move : a time and a place for cyclin A2 and cyclin B1 in the human cell cycle

    Author : Helena Silva Cascales; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The ultimate aim of the cell cycle is to create an identical daughter cell. Therefore, correct progression through the different phases of the cell cycle is crucial to ensure faithful cell division. READ MORE

  5. 3. Genomic instability and tumor progression : a cytochemical, molecular biological and cytogenetic study of human tissue from uterine cervix, colon, breast and ovary

    Author : Harald Blegen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cervical; colorectal; breast; ovarian neoplasia; proliferation; DNA ploidy; cyclins; P53; CGH;

    Abstract : Disruption of cell cycle checkpoint control is believed to be common in human carcinomas. To elucidate how cell cycle defects and genomic instability cooperate we investigated the pathogenesis of carcinomas by using four different models of tumor progression in human tissue samples i.e. from the uterine cervix, colon, breast and ovary. READ MORE

  6. 4. Tumor progression in melanocytic lesions : biological and diagnostic implications

    Author : Lena Kanter-Lewensohn; Karolinska Institutet; Karolinska Institutet; []
    Keywords : melanocytic tumors; MIB-1; Bcl-2; IGF-1R. p27; cyclins; cdks and Tamoxifen;

    Abstract : Cutaneous malignant melanoma has an annual incidence of 5% in Sweden, with about 1500 cases diagnosed yearly. In routine histopathology there are diagnostic difficulties in the analysis of pigmented lesions. READ MORE

  7. 5. G1-phase cyclin expression in neoplastic B cells

    Author : Richard Scuderi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cell cycle; G1 phase; cyclin D; cyclin E; EBV; Burkitt s; B-ALL; B-CLL; apoptosis;

    Abstract : By virtue of the role of G1-phase cyclin proteins as regulators of differentiation, proliferation, and apoptosis, their improper expression can lead to altered cellular homeostasis and tumor formation. Cyclins provide the regulatory partner for cyclin-cdk complexes whose enzymatic activity drives cell cycle progression. READ MORE