Search for dissertations about: "cystatins"

Showing result 1 - 5 of 9 swedish dissertations containing the word cystatins.

  2. 1. Structural and Functional Studies on Human Type 2 Cystatins

    Author : Marcia Alvarez Fernandez; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical chemistry; Klinisk kemi; structural- functional relationships.; protein crystallography; enzyme kinetics; inhibitors; cathepsins; legumains; cystatins; cysteine peptidases;

    Abstract : Proteolytic enzymes are enzymes that hydrolyze peptide bonds in peptides and proteins. This ability to carry out protein degradation is essential for many cellular and extracellular processes that occur in all living organisms. Cysteine peptidases constitute a class of proteolytic enzymes. READ MORE

  4. 2. Cellular Effects of Cystatins

    Author : Samar Hunaiti; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cystatin C; Cystatin D; Galectin-1; Puncta assay; HoloMonitor; Cancer cells; Apoptosis; Cathepsin C;

    Abstract : The exact cellular functions of cystatins are still unknown, and the molecular mechanism leading to their internalization into cells is not yet fully understood. Commonly the cystatins are known to inhibit human lysosomal cysteine proteases (cysteine cathepsins) and it is supposed that this is their primary physiological role. READ MORE

  5. 3. The Testatin/Cres subgroup of family 2 cystatins in sexual development

    Author : Jessica Frygelius; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The genetic sex in mammals is established at fertilization, where an XX chromosome complement will lead to female development and an XY genotype will result in male development. Thereafter, sex determination is initiated with expression of the Y-linked factor Sry in XY gonads, leading to testis formation, while in the absence of Sry expression an ovary is formed. READ MORE

  6. 4. Type 2 Cystatins. Studies on the role of the major cystatin, cystatin C, in mice and on properties and distribution of the novel human cystatins F, G, H and I

    Author : Carl-Michael Nathanson; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical chemistry; Klinisk kemi; enzyme kinetics; eosinophilic granulocytes; expression pattern; pleural effusion; knockout mouse; Cysteine peptidase; cystatin;

    Abstract : The aim the thesis work was to study the human cystatins C, E/M, F, G, H and I both in vivo and in vitro. A mouse devoid of cystatin C was used for the cystatin C studies. The levels of cystatins C, E/M and F were measured in pleural effusion samples of patients with various lung disorders. READ MORE

  7. 5. HUMAN CYSTATIN C. Studies on structure and function of a cysteine proteinase inhibitor. Relation to hereditary cerebral haemorrhage with amyloidosis

    Author : Magnus Abrahamson; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : cystatin C; protein structure; amyloid-; brain health; Protease inhibitor;

    Abstract : Six different cysteine proteinase inhibitors (cystatins) were isolated from human urine and characterized. Five of them... READ MORE