Search for dissertations about: "cysteine"
Showing result 1 - 5 of 272 swedish dissertations containing the word cysteine.
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1. Studies on secreted cysteine proteases of Streptococcus pyogenes : IdeS and SpeB
Abstract : The pathogen Streptococcus pyogenes is a significant cause of human morbidity and mortality. Most of the work in this thesis is focused on streptococcal virulence factor IdeS, but the thesis also features work on SpeB, another streptococcal virulence factor. READ MORE
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2. DNA checkpoint override and redox signaling in Schizosaccharomyces pombe
Abstract : This thesis covers intracellular stress signaling through genotoxic stress, overriding of checkpoint control, as well as cellular redox status in hypoxic and oxidative stress Papers I and II: Caffeine has been shown to override cell cycle checkpoints in humans as well as in the fission yeast Schizosaccharomyces pombe. Understanding of the mechanism may aid in the development of compounds with similar overriding mechanisms for sensitization in cancer therapy. READ MORE
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3. Cell-Penetrating Penetratin Peptides - Mechanistic Studies on Uptake Pathways and DNA Delivery Efficiency
Abstract : Delivery of gene-targeted drugs is limited by the inherently poor capacity of nucleic acids to overcome the membrane barrier of the cell, and development of vectors that can promote uptake is therefore crucial. Cell penetrating peptides (CPPs) have emerged as promising vector candidates due to their ability to deliver a wide range of macromolecular cargos into cells. READ MORE
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4. Light Protection in Plants: Characterisation of Violaxanthin de-epoxidase
Abstract : Plants and algae need light to drive the photosynthetic machinery. An excess of light will, however, result in damage to the photosynthetic machinery and to the rest of the organism. The surplus of energy, when exposed to light stress is converted into less harmful heat energy through a process called non-photochemical quenching. READ MORE
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5. CYSTATIN C AND NEUROENDOCRINE DIFFERENTIATION IN THE MALE REPRODUCTIVE SYSTEM AND IN PROSTATE CANCER
Abstract : Cystatins are endogenous protease inhibitors that regulate the proteolytic activities of family C1 (papain-like) cysteine proteases, such as human cathepsins B, H, K, L, and S. Cystatin C shows the fastest inhibition and the highest affinity of all cystatins towards lysosomal cysteine proteases in general and is widespread in human tissues and body fluids. READ MORE