Search for dissertations about: "cytochrome p450 inhibition"
Showing result 1 - 5 of 34 swedish dissertations containing the words cytochrome p450 inhibition.
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1. Cytochrome P450 enzymes affected by artemisinin antimalarials-pharmacokinetic and pharmacogenetic aspects
Abstract : With more than 500 million cases and at least 1 million deaths each year, malaria is a major global health problem. The main problem with malaria control is the emerging drug resistance among parasites causing the infection. Consequently, there is an urgent need for new drugs. READ MORE
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2. Interactions between cytochrome P450 and estrogenic compounds in fish
Abstract : DISSERTATION ABSTRACT Hasselberg, Linda. Interactions between cytochrome P450 and estrogenic compounds in fish. Department of Zoophysiology, Göteborg University, Box 463, SE-405 30 Göteborg, Sweden Contamination by various pollutions is an environmental concern. READ MORE
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3. In vitro and in vivo studies of artemisinin endoperoxides
Abstract : Artemisinin and its semi-synthetic derivatives (eg. Artemether/ARM, artesunate/ARS, dihydroartemisinin/DHA) play an important role in combating malaria, and treatments containing an artemisinin derivative (artemisinin-based combination therapies, ACTs) are today the standard treatment worldwide for Plasmodium falciparum malaria. READ MORE
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4. Cytochrome P450: Metabolism and Inhibition. Computational and Experimental Studies
Abstract : .... READ MORE
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5. Cytochrome P450 2E1 - relevance for central dopamine neurotransmission and Parkinson's disease
Abstract : Introduction: The enzyme cytochrome P450 2E1 (CYP2E1) has been found in dopamine (DA) containing brain regions that are of relevance for Parkinson?s disease (PD), and is known to generate reactive oxygen species (ROS), toxic molecules that have been implicated in the degeneration of DA neurones. In addition, previous investigations have indicated that inhibition of CYP2E1 increases extracellular DA in the substantia nigra, a nucleus which degenerates in PD. READ MORE