Search for dissertations about: "cytogenetics"

Showing result 1 - 5 of 78 swedish dissertations containing the word cytogenetics.

2. 1. Genetic analyses of multiple myeloma and related plasma cell dyscrasias

   Author : Therese Nilsson; Avdelningen för klinisk genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetik; cytogenetik; cytogenetics; Genetics; FISH; cytogenetic; multiple myeloma; MGUS;

   Abstract : Acquired genetic changes have proved to be of diagnostic and prognostic importance in different hematologic malignancies as well as in some solid tumor types. However, although multiple myeloma (MM), an incurable disease, and its proceeding stage monoclonal gammopathy of undetermined significance (MGUS) are quite common, little is known about the karyotypic features of these plasma cell dyscrasias. READ MORE

4. 2. Cytogenetic studies of primary and metastatic breast cancer

   Author : Adewale Adeyinka; Avdelningen för klinisk genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; histokemi; cytokemi; Histologi; tissue culture; cytochemistry; histochemistry; Histology; metastases; prognosis; male breast cancer; breast cancer; trisomy 12; Cytogenetics; chromosomes; vävnadskultur; Clinical genetics; Klinisk genetik;

   Abstract : A series of primary and metastatic breast carcinomas obtained from female and male patients were cytogenetically analysed. Trisomy 12 was identified as a recurrent and sometimes early event in breast carcinogenesis. READ MORE

5. 3. Genetic studies on cardiovascular disease - identification of novel drug targets

   Author : Stefan Amisten; Kardiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Medicin människa och djur ; Medicine human and vertebrates ; platelet; single nucleotide polymorphism; myocardial infarction; stent; G-protein coupled receptor; P2Y; cytogenetics; Genetik; cytogenetik; Cardiovascular system; Kardiovaskulära systemet;

   Abstract : The aim of this thesis was to identify novel potential drug targets of cardiovascular disease with a focus on G-protein coupled receptors. We identified a common genetic variant of the ATP receptor P2Y11, where an alanine is substituted with a threonine at position 87 of the P2Y11 receptor that increases the risk of developing acute myocardial infarction. READ MORE

6. 4. A new perspective on avian phylogeny - a study based on mitochondrial genomes

   Author : Anna Bartosch-Härlid; Biologiska institutionen; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Genetics; thyroid; neoteni; mitochondrial DNA; phylogeny; Class Aves; Palaeognathae; cytogenetics; Genetik; cytogenetik;

   Abstract : The Class Aves (birds) is generally divided into two main groups - the Palaeognathae and the Neognathae. Paleognathous birds are the flightless ratites and the tinamous, while Neognathae include all other extant birds (more than 9,000 species). READ MORE

7. 5. On the binding of growth-promoting polyamines to proteoglycans: Implications for growth-regulation and polycation-mediated gene transfer

   Author : Mattias Belting; Institutionen för experimentell medicinsk vetenskap; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; cationic lipid.; gene transfer; gene therapy; cell growth; polyamine transport; spermine; polyamine; growth-inhibition; heparan sulphate; dermatan sulphate; Proteoglycan; glycosaminoglycan; cytogenetics; Genetik; cytogenetik;

   Abstract : Initial investigations were directed at studying the interaction between polyamines and various glycosaminoglycans (GAGs). The polyamine spermine displayed binding to dermatan sulphate (DS) and heparan sulphate (HS) with similar (Kd, 3.9 x 10-4 M) and higher (Kd, 0.37 x 10-6 M) affinity, respectively, than to DNA. READ MORE