Search for dissertations about: "damage associated molecular patterns"

Showing result 1 - 5 of 23 swedish dissertations containing the words damage associated molecular patterns.

2. 1. Replication Dynamics in the DNA Damage Response

   Author : Petra Groth; Thomas Helleday; Geroge Iliakis; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; DNA damage; DNA replication; homologous recombination; DNA double strand-breaks; ionizing radiation; alkylating agents; NATURAL SCIENCES; NATURVETENSKAP; Genetics; Genetik; molekylärgenetik; Molecular Genetics;

   Abstract : Faithful DNA replication is essential and the induction of replication stress may have profound effects on genomic integrity. This is demonstrated by the formation of DNA double strand breaks (DSBs), considered to be the most toxic DNA lesions, at stalled replication forks. READ MORE

4. 2. Gene Expression Patterns in a Rat Model of Human Endometrial Adenocarcinoma

   Author : Sandra Karlsson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rat; complex disease; Endometrial adenocarcinoma; gene expression profiling; cDNA microarrays; candidate genes; Molecular biology; Medical sciences;

   Abstract : Endometrial cancer develops from the endometrium of the uterus and is the most common pelvic malignancy diagnosed in women in the western society. Similar to all cancer diseases, endometrial cancer is a disorder that results from complex patterns of genetic and epigenetic alterations involved in the malignant transformation. READ MORE

5. 3. Microarray Based Gene Expression Analysis in Cancer Research

   Author : Cecilia Laurell; Joakim Lundberg; Peter Nilsson; Karin Dahlman-Wright; KTH; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adrenocortical tumour; apoptosis; cancer; classification; gene expression; microarray; p53; RNA amplification; Molecular biology; Molekylärbiologi;

   Abstract : Biotechnological inventions during the 20th century have resulted in a wide range of approaches for explorations in the functional genomics field. Microarray technology is one of the recent advances which have provided us with snapshots of which genes are expressed in cells of various tissues and diseases. READ MORE

6. 4. Molecular architecture of meiotic chromosomes

   Author : Ivana Novak; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Meiosis; Chromosome architecture; Synaptonemal complex; Cohesin complex;

   Abstract : Faithful chromosome segregation at each cell division is essential as the formation of cells with an abnormal number of chromosomes (aneuploid cells) can result in infertility, developmental defects or cancer. Aneuploidy occurs in approximately 20% of all conceptions, causing infertility and embryo death. READ MORE

7. 5. Acute pancreatitis, from local defense to remote organ injury

   Author : Hamid Akbarshahi; Lund Kirurgi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute pancreatitis; heparan sulfate; damage associated molecular patterns; toll-like receptor4; MyD88; IRF-3; acute lung injury; macrophages; transforming growth factor-beta; Smad;

   Abstract : Acute pancreatitis (AP) is an inflammatory disease of the pancreas. Acute abdominal pain is the most common symptom. Pancreatic injury is mild in 80% of patients, who recover without complications. The remaining patients have a severe disease with local and systemic complications such as acute lung injury (ALI). READ MORE