Search for dissertations about: "danger signal"

Showing result 1 - 5 of 18 swedish dissertations containing the words danger signal.

  2. 1. Human eosinophils and their activation by allergens via danger signal receptors

    Author : Elin Redvall; Göteborgs universitet; []
    Keywords : human eosinophils; danger signals; allergen; formyl peptide receptors; CCR3; chemotaxis; degranulation; free oxygen radicals; receptor desensitization;

    Abstract : Human eosinophilic granulocytes are polymorphonuclear cells with a powerful arsenal of cytotoxic substances in their granules, which are mainly found in the gastrointestinal mucosa, and the respiratory and genitourinary tracts. Their physiological role is incompletely understood, although it is likely they protect the mucosal surfaces, perhaps by recognizing danger signals present on microorganisms or released from damaged tissue. READ MORE

  4. 2. Activation of human eosinophils by exogenous danger signals

    Author : Lena Svensson; Göteborgs universitet; []
    Keywords : Human eosinophils; danger signals; WKYMVm; bacteria; allergen; chemotaxis; CR3; free oxygen radicals; degranulation; formyl peptide receptor;

    Abstract : Eosinophilic granulocytes are leukocytes that reside in the gastrointestinal and respiratory tracts. Their function in health is unknown. READ MORE

  5. 3. Autoimmune Regulator Deficient Mice, an Animal Model of Autoimmune Polyendocrine Syndrome Type I

    Author : Signe Hässler; Ola Winqvist; Olle Kämpe; Bertrand Huard; Uppsala universitet; []
    Keywords : Molecular medicine; autoimmune regulator; autoimmune polyendocrine syndrome type I; peripheral tolerance; antigen presenting cells; autoimmunity; danger signal; knockout mice; Molekylärmedicin;

    Abstract : Autoimmune diseases develop when the immune system fails to distinguish self from non-self or when the immune system is hypersensitive to endogenous or exogenous danger signals, or when a tissue erroneously sends a danger signal to the immune system. The education of the immune system to distinguish self from non-self is mainly carried out in the thymus and gives rise to central tolerance, whereas the ability to sense a danger or a healthy tissue constitutes peripheral tolerance. READ MORE

  6. 4. Mast cell responses to danger signals

    Author : Mattias Enoksson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Detecting and responding to danger is a paramount function of the immune system. Compounds heralding danger can be divided into two groups: exogenous and endogenous danger signals. READ MORE

  7. 5. Innate immune modulation in atherosclerosis : with focus on ApoB100 derived danger associated signal 1 (ApoBDS-1)

    Author : Yajuan Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Elevated level of LDL is the most important risk factor for atherosclerosis. ApoB100 is the only unexchangeable protein in LDL particle. Recent reports have shown that native peptides of ApoB100 trigger activation of adaptive immune responses. Whether ApoB100 can activate innate immune response is unknown. READ MORE