Search for dissertations about: "degradation studies of drugs"

Showing result 1 - 5 of 49 swedish dissertations containing the words degradation studies of drugs.

2. 1. Engineering of the Ultra-stable Cystine Knot Framework of Microproteins : Design, Chemical Synthesis and Structural Studies

   Author : Teshome Leta Aboye; Ulf Göransson; Julio A. Camarero; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cyclotides; cystine knot; protein engineering; NMR; solid phase; disulfide rich; ultra-stable; microprotein; PHARMACY; FARMACI; Medicinal Chemistry; Läkemedelskemi;

   Abstract : Ultra-stable cystine knotted microproteins, in which two disulfides and their connecting backbones form a circle that is penetrated by the third disulfide bonds, have attracted high interest due to their resistance to degradation in vitro and potential for the development of peptide drugs. This thesis gives new insights into engineering of that framework of microproteins, including approaches to their chemical synthesis, backbone engineering, structural and biological evaluations. READ MORE

4. 2. Stability of zopiclone in whole blood : Studies from a forensic perspective

   Author : Gunnel Nilsson; Robert Kronstrand; Johan Ahlner; Fredrik Kugelberg; Linköpings universitet; []
   Keywords : MEDICINE; MEDICIN;

   Abstract : Bio‐analytical results are influenced by in vivo factors like genetic, pharmacological and physiological conditions and in vitro factors like specimen composition, sample additives and storage conditions. The knowledge of stability of a drug and its major metabolites in biological matrices is very important in forensic cases for the interpretation of analytical results. READ MORE

5. 3. Experimental studies of corneal neovascularisation

   Author : Branka Samolov; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The cornea contains no vessels, which is a prerequisite for the maintenance of its transparency. Vessel ingrowth leads to opacification resulting in visual impairment, sometimes complete blindness. READ MORE

6. 4. Effects of burns and vasoactive drugs on human skin : Clinical and Experimental studies using microdialysis

   Author : Anders Samuelsson; Folke Sjöberg; Ola Winsö; Linköpings universitet; []
   Keywords : MEDICINE; MEDICIN;

   Abstract : Patients who require critical care, including those with burns, are affected by a systemic inflammatory reaction, which at times has consequences such as multiple organ dysfunction and failure. It has become increasingly evident that other factors important in the development of organ dysfunction are disturbances at the tissue level, in the microcirculation. READ MORE

7. 5. Structural and functional studies of proteins of medical relevance : Protein-ligand complexes in cancer and novel structural folds in bacteria

   Author : Robert Gustafsson; Pål Stenmark; Pavlína Řezáčová; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; X-ray crystallography; Cancer; MTH1; oxidised nucleotides; MTHFD2; nucleotide metabolism; one-carbon metabolism; Botulism; Botulinum neurotoxin; OrfX; OrfX gene cluster; Biochemistry; biokemi;

   Abstract : X-ray crystallography is a tool for determining the structures of proteins and protein-ligand complexes. In this thesis the method has been employed to study several proteins of medical relevance.Cancer is a terrible disease, severely impacting those affected, as well as their family and friends. READ MORE