Search for dissertations about: "deletion mutant"
Showing result 1 - 5 of 101 swedish dissertations containing the words deletion mutant.
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1. Genes and Physiological Role of the Eukaryotic Nicotinamide Nucleotide Transhydrogenase
Abstract : Nicotinamide nucleotide transhydrogenase (NNT, EC 1.6.1. READ MORE
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2. Novel Fatty Acid Dioxygenases of Human and Plant Pathogenic Fungi : Studies by Gene Deletion and Expression
Abstract : The dioxygenase-cytochrome P450 fusion proteins (DOX-CYP) comprise a heme-containing enzyme family that shares structural and catalytic properties with mammalian prostaglandin H (PGH) synthases. 7,8-Linoleate diol synthase (7,8-LDS) of Gaeumannomyces graminis was first characterized, and DOX-CYP enzymes are of mechanistic and biological interest. READ MORE
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3. Mutation profile at the hprt locus in T-cells of non-smoking males
Abstract : Extensive studies have been done on mutations in several marker genes in order to predict health consequences such as carcinogenesis. However, more information about mutations arising in vivo in somatic cells is needed to understand the relationship between the different factors involved in mutagenesis such as DNA damage, DNA repair capacity and individual susceptibility, and to elucidate the influence of endogenous mechanisms and environmental exposures. READ MORE
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4. Identification and characterisation of SMIM1 variants determining the Vel blood group
Abstract : The Vel blood group antigen is present on red blood cells from all humans except rare Vel-negative individuals, who can form antibodies to Vel in response to transfusion or pregnancy. It was first described in 1952 as a high incidence antigen, while the molecular background was recently discovered to be a 17-bp deletion in Small Integral Membrane Protein 1, that causes a frame-shift mutation and abolishes SMIM1 expression, thus creating a Vel-negative phenotype. READ MORE
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5. Neuropeptide Y (NPY) and glutamate transporter (GLAST) in behavioral models of psychiatric disorders
Abstract : For many psychiatric disorders there are still unmet needs for treatment. Using genetically modified mice provide means to study the systems that underlie these disorders as well as identifying potential novel targets for treatment. READ MORE