Search for dissertations about: "destabilization"
Showing result 1 - 5 of 72 swedish dissertations containing the word destabilization.
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1. Engineering Proteinaceous Ligands for Improved Performance in Affinity Chromatography Applications
Abstract : .... READ MORE
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2. Homotrimeric dUTPases : Principles of Catalysis and Inhibitor Design
Abstract : The ubiquitous enzyme dUTPase hydrolyzes dUTP into dUMP and pyrophosphate, preventing DNA fragmentation and cell death due to accumulation of dUTP. Inhibitors of dUTPase could serve as drugs in the treatment of cancers and infectious diseases. This thesis presents five studies. READ MORE
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3. Influence of Aromaticity on Excited State Structure, Reactivity and Properties
Abstract : This thesis describes work that could help development of new photochemical reactions and light-absorbing materials. Focus is on the chemical concept "aromaticity" which is a proven conceptual tool in developing thermal chemical reactions. It is here shown that aromaticity is also valuable for photochemistry. READ MORE
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4. Insulin-Producing Cells, Iron, Oxidative Stress, and Lysosomal Pathology
Abstract : Accumulating evidence suggests that injnries caused by oxygen-derived radicals contribute to the destruction of pancreatic islet ß-cells in autoinnnune diabetes mellitus (diabetes type I, or IDDM). Oxidative stress may be caused by an enhanced production of oxygen-derived radicals, or by a decreased scavenging of such molecules. READ MORE
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5. How transient interactions in the crowded cytosol affect protein mobility and stability
Abstract : Most biochemical reactions have evolved in crowded intracellular environments. However, the complexity of intracellular environments is often neglected in structural or functional studies of proteins. READ MORE