Search for dissertations about: "determination of of drugs by HPLC"

Found 4 swedish dissertations containing the words determination of of drugs by HPLC.

  2. 1. Development and Validation of HPLC Methods for Analytical and Preparative Purposes

    Author : Johan Lindholm; Torgny Fornstedt; Karin Caldwell; Karl-Gustaf Wahlund; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemistry; High performance liquid chromatography HPLC ; Analytical biotechnology; Sample preparation; Diode-array-detection DAD ; Mass spectrometry MS ; Validation; Preparative chromatography; Competitive isotherm parameters; Perturbation peak PP method; Kemi; Chemistry; Kemi;

    Abstract : This thesis concerns the development and validation of high performance liquid chromatography (HPLC) methods aimed for two industrially important areas: (i) analysis of biotechnological synthesis and (ii) determination of adsorption isotherm parameters. There is today a lack of detailed recommendations for analytical procedures in the field of biotechnological production of drugs. READ MORE

  4. 2. Towards more selective sorbents for extraction of drugs and biomarkers from biological fluids using molecularly imprinted polymers

    Author : Mohammad Mahdi Moein; Mohamed Abdel-Rehim; Milton L. Lee; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; molecularly imprinted polymer; sol-gel; solid phase extraction; microextraction by packed sorbent; monolithic column; Analytical Chemistry; analytisk kemi;

    Abstract : Sample preparation has a critical role as a first step in analytical processes, especially in bioanalysis and environmental analysis. A good sample preparation technique should be robust and stable, regardless of the sample matrix. READ MORE

  5. 3. Porphyrins and heme in microorganisms : Porphyrin content and its relation to phototherapy and antimicrobial treatments in vivo and in vitro

    Author : Jonas Fyrestam; Conny Östman; Jonas Bergquist; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Porphyrins; heme; phototherapy; antimicrobial resistance; singlet oxygen; photosensitizer; bacteria; HPLC-MS MS; oral bacteria; Aggregatibacter actinomycetemcomitans; Porphyromonas gingivalis; Escherichia coli; Analytical Chemistry; analytisk kemi;

    Abstract : One of the greatest threats to human health is increasing antimicrobial resistance among pathogens, and finding alternatives for treatment of bacterial infections is of highest importance together with a more controlled use of antibiotics. Porphyrins and heme have both been shown to be a promising class of compounds for inactivation of bacteria; porphyrins by their excellent properties to act as a photosensitizer, and heme by its importance as an iron source during a bacterial infection in vertebrates. READ MORE

  6. 4. Amine transaminase: Process development aspects for chiral amine synthesis

    Author : Tim Börner; Bioteknik; []
    Keywords : ;

    Abstract : Many modern drugs contain chiral amine moieties and the need for more efficient processes to synthesize these amines in high optical purity and concentration are greatly demanded by the fine chemical and pharma industry. Amine transaminases (ATA) allow for the direct asymmetric synthesis of optically pure amines from ketone substrates. READ MORE