Search for dissertations about: "dexamethasone"

Showing result 1 - 5 of 132 swedish dissertations containing the word dexamethasone.

  2. 1. Mechanisms of Sensitization to Apoptosis in Multiple Myeloma

    Author : Anna Hammarberg; Helena Jernberg Wiklund; Kenneth Nilsson; Federico Caligaris-Cappio; Uppsala universitet; []
    Keywords : Pathology; multiple myeloma; apoptosis; IGF-1; mTOR; IAP; GSK3; rapamycin; PPP; dexamethasone; CT99021; Patologi;

    Abstract : Multiple myeloma (MM) is a hematological tumor of plasma blast/plasma cell origin heterogeneous with respect to the morphological differentiation stage of the tumor cells, genetic alterations and course of disease. A challenge in MM research is to overcome resistance to therapy, which inevitably arises. READ MORE

  4. 2. Hormonal programming and adrenal function. Studies in children and in a rat model

    Author : Jovanna Dahlgren; Göteborgs universitet; []
    Keywords : Children; cortisol; dehydroepiandrosterone sulphate; small for gestational age; short stature; cytokines; dexamethasone; insulin sensitivity; androgenization;

    Abstract : Prenatal events during specific time windows have been found to be followed by permanent changes affecting neuroendocrine, so called programming. Undernutrition, placental dysfunction or maternal stress, are apparent examples of such stimuli. READ MORE

  5. 3. Mechanisms of therapy resistance in acute lymphoblastic leukemia

    Author : Kinjal Shah; Avdelningen för translationell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALL; B-ALL; T-ALL; dexamethasone; FLT3; Signaling pathways; BCL2; resistance; PLK1; synergy;

    Abstract : Acute lymphoblastic leukemia (ALL) is a highly aggressive pediatric cancer that can affect both B cells and T cells. The advent of new therapies has increased the cure rates for both B-ALL and T-ALL patients. However, some patients still experience relapse with a variable response to the treatment and display poor survival. READ MORE

  6. 4. Pathogenesis and treatment of chemical-induced lung injury

    Author : Elisabeth Wigenstam; Anders Bucht; Thomas Sandström; Kjell Larsson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chemical-induced lung injury; dexamethasone; melphalan; vitamin E; respiratory mechanics; lungmedicin; Lung Medicine;

    Abstract : Inhalation of chemical substances can cause irritation to airways and in high doses acute airway injury. When mice are exposed to the alkylating nitrogen mustard analogue melphalan they develop an acute airway inflammation with a rapid influx of neutrophils to the lungs. READ MORE

  7. 5. Drug Eluting Hydrogels : Design, Synthesis and Evaluation

    Author : Lage Ahrenstedt; Deon Bezuidenhout; Michael Malkoch; University of Cape Town; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Drug delivery; PEGylation; Rapamycin; Dexamethasone; Controlled release; Hydrogels; Slow release;

    Abstract : Hydrogels have successfully proved themselves useful for drug delivery applications and several delivery routes have been developed over the years. The particular interest in this work was to design, synthesise and evaluate in situ forming drug eluting hydrogels, which have the potential to ameliorate the healing of cardiovascular diseases. READ MORE