Search for dissertations about: "diabetes and mouse model"

Showing result 1 - 5 of 121 swedish dissertations containing the words diabetes and mouse model.

  2. 1. Berries in Prevention of Metabolic Disease – focus on obesity, diabetes and gut microbiota

    Author : Lovisa Heyman; Molekylär nutrition; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; obesity; type 2 diabetes; berries; low-grade inflammation; gut microbiota; hepatic steatosis; gene expression; DNA methylation; lingonberry; blackcurrant; bilberry; açai;

    Abstract : The increasing prevalence of obesity is a worldwide health problem closely linked to diet and lifestyle factors. Obesity is associated with increased risk of several metabolic disorders including insulin resistance, nonalcoholic fatty liver disease and type 2 diabetes. READ MORE

  4. 2. The MEN 1 Pancreas : Tumor Development and Haploinsufficiency

    Author : Margareta Halin Lejonklou; Britt Skogseid; Peter Stålberg; Andreea Barbu; Gerard Doherty; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEN 1; PNET; tumor development; haploinsufficiency; survivin; Endokrinologi och Diabetologi; Endocrinology and Diabetology;

    Abstract : Multiple Endocrine Neoplasia Type I Syndrome (MEN 1) is a monogenic autosomal dominantly inherited cancer syndrome caused by a heterozygous loss of the MEN1 gene, predisposing for endocrine cell proliferation and tumor formation. MEN 1 carriers classically develop tumors in endocrine organs; the parathyroids, the endocrine pancreas, and the pituitary. READ MORE

  5. 3. Dissecting the role of micro-RNAs in diabetes

    Author : Caroline Bolmeson; Create Health; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Type 2 diabetes; micro-RNA; Dicer; beta-cell function; insulin secretion; glucose; NOD mouse; Goto-Kakizaki rat; human islets; thymocytes; apoptosis;

    Abstract : The role of miRNAs in pancreatic islets and β-cell function and in the development of diabetes in human and rodents have been investigated in this thesis. Dicer1 was specifically deleted in vivo in pancreatic β-cells under the RIP-promoter in mice. READ MORE

  6. 4. Estrogen and Serotonin – old dogs, new tricks, Implications for pancreatic beta-cell function

    Author : Alexander Balhuizen; Celiaki och diabetes; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes; Estrogen; Serotonin; Pancreatic islets; Insulin resistance; Beta-cell function; GPCR;

    Abstract : Islet hormone secretion is tightly regulated by metabolic status as well as local and circulating factors. These factors can activate different receptors on the pancreatic islet cells, for instance G-protein coupled receptors (GPCRs). READ MORE

  7. 5. Regulation of Autoimmunity and Inflammation by microRNAs and Environmental Factors

    Author : Neivis Tormo-Badia; Diabetes - immunovirologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Tolerance is crucial for maintaining immunological balance and avoid autoimmune diseases like type 1 diabetes and the inflammatory bowel disease, ulcerative colitis (UC). In Study I, we have investigated the regulatory role of a class of noncoding RNAs, the miRNAs, during thymocyte development of the where central tolerance is established. READ MORE