Search for dissertations about: "diabetes type 1 in 2013"

Showing result 1 - 5 of 38 swedish dissertations containing the words diabetes type 1 in 2013.

2. 1. Fathers involved in children with type 1 diabetes : finding the balance between disease control and health promotion

   Author : Åse Boman; Ina Borup; Elisabeth Dahlborg-Lyckhage; Lene Povlsen; Ragnar Hanås; Torill Marie Bogsner Larsen; Högskolan Väst; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; children; fathers’ involvement; health promotion; pediatric diabetes team; type 1; Folkhälsovetenskap; Public health science;

   Abstract : Background:Type I diabetes is a chronic disease that places great demands on the child and family. Parental involvement has been found to be essential for disease outcome. READ MORE

4. 2. Reign in Blood : Immune Regulation in Type 1 Diabetes

   Author : Mikael Pihl; Rosaura Casas; Johnny Ludvigsson; Marianne Quiding-Järbrink; Linköpings universitet; []
   Keywords : ;

   Abstract : Type 1 Diabetes (T1D) is an autoimmune disease resulting in insulin deficiency as a result ofautoimmune destruction of pancreatic β-cells. Preserving β-cell function in patients with T1D would be of great benefit since patients with sustained endogenous insulin secretion are known to suffer less from secondary complications due to hyperglycemia. READ MORE

5. 3. Mechanisms of defective insulin secretion in type 2 diabetes

   Author : Taman Mahdi; Diabetes - öpatofysiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 2 diabetes; Insulin secretion; TCF7L2; ADRA2A; KCNQ1; SFRP4; interleukin-1B;

   Abstract : Defective insulin secretion from the pancreatic B-cells is a central feature in type 2 diabetes (T2D). There is a strong hereditary component in type T2D, but the underlying pathophysiology remains largely unknown. READ MORE

6. 4. Enterovirus Implications in Type 1 Diabetes

   Author : Monika Hodik; Hober didier; Uppsala universitet; []
   Keywords : Enterovirus; Coxsackie B virus; Type 1 diabetes; Pancreatitis;

   Abstract : Human enteroviruses (HEVs), particularly Coxsackie B viruses (CVBs), might trigger the onset of type 1 diabetes (T1D), either by direct infection of the insulin-producing beta-cells or by an indirect inflammatory response. The overall aim of this thesis was to study the tropism of HEVs in isolated human pancreatic cell clusters in vitro including virus effects on islet function, gene-expression and ultrastructure. READ MORE

7. 5. Mechanisms by which variants in the TCF7L2 gene increase the risk of developing Type 2 diabetes

   Author : Yuedan Zhou; diabetes och endokrinologi Genomik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TCF7L2; rs7903146; Type 2 diabetes; β cell function; β cell survival; insulin secretion; proinsulin synthesis; proinsulin-to-insulin conversion; insulin maturation; open chromain; exon skipping; p53; TP53INP1; ISL1; MAFA; NEUROD1; PDX1; NKX6.1; PCSK1; PCSK2; SLC30A8; GWAS.;

   Abstract : Type 2 diabetes mellitus (T2DM) is a heterogeneous disease with a multifactorial aetiology comprising of genetic and environmental factors. The common variant most highly associated with T2DM known to date is a SNP rs7903146 in the TCF7L2 gene. However, the role TCF7L2 plays in the development of T2DM was unclear. READ MORE