Search for dissertations about: "diabetic nephropathy RATS"

Showing result 1 - 5 of 10 swedish dissertations containing the words diabetic nephropathy RATS.

2. 1. The Role of Mitochondrial Uncoupling in the Development of Diabetic Nephropathy

   Author : Malou Friederich Persson; Fredrik Palm; Richard K. Porter; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kidney; mitochondria; Uncoupling Protein-2; Adenosine Nucleotide Transporter; uncoupling; diabetes; diabetic nephropathy; db db; dinitrophenol; Coenzyme Q10; oxygen; rats; mice; Physiology; Fysiologi; Medical Cell Biology; Medicinsk cellbiologi;

   Abstract : Diabetes is closely associated with increased oxidative stress, especially originating from the mitochondria. A mechanism to reduce increased mitochondria superoxide production is to reduce the mitochondria membrane potential by releasing protons across the mitochondria membrane. READ MORE

4. 2. Pathomechanism of diabetic nephropathy

   Author : Anna Körner; Karolinska Institutet; Karolinska Institutet; []
   Keywords : diabetic nephropathy; hyperflltration; Na ; K - ATPase; Dahl rats; salt sensitive hypertension; glomerulosclerosis; polyol pathway activation; oxidative stress;

   Abstract : Diabetic nephropathy is today the most common cause of end stage renal failure. The risk for developing overt diabetic nephropathy is considerably reduced by antihypertensive treatment, and adequate control of blood glucose. However, there is a need for additional and even more efficient tools to prevent this complication of diabetes. READ MORE

5. 3. Aspects of Regulation of GFR and Tubular Function in the Diabetic Kidney : Roles of Adenosine, Nitric Oxide and Oxidative Stress

   Author : Patrik Persson; Fredrik Palm; Peter Hansell; Bengt Rippe; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetes; diabetic nephropathy; glomerular filtration rate; renal blood flow; insulin; renal hemodynamics; micropuncture; oxygen; NADPH-oxidase; apocynin; streptozotocin; l-arginine; CGS21680; rats; mice; Physiology; Fysiologi; Medical Science; Medicinsk vetenskap;

   Abstract : Diabetic nephropathy is the main cause for initiation of renal replacement therapy and early symptoms in patients include increased glomerular filtration rate (GFR), decreased oxygen tension and albuminuria, followed by a progressive decline in GFR and loss of kidney function. Experimental models of diabetes display increased GFR, decreased tissue oxygenation and nitric oxide bioavailability. READ MORE

6. 4. Novel Approaches to Treatment and Prevention of Diabetic Nephropathy

   Author : Lina Nordquist; Mats Sjöquist; Peter Bergsten; William J. Welch; Uppsala universitet; []
   Keywords : Physiology; Diabetes; Nephropathy; C-peptide; Microneedle; Renal; GFR; Oxygen Consumption; Reabsorption; Fysiologi;

   Abstract : Several studies have reported beneficial effects of C-peptide supplementation in diabetic patients and animal models of insulinopenic diabetes. However, it is also established that good glycemic control is essential to minimize the risk of diabetes-induced complications. READ MORE

7. 5. Diagnostic and prognostic value of proteinuria in chronic renal diseases

   Author : Omran Bakoush; Njurmedicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Urology; Hypertension.; Glomerulonephritis; IgM; Albuminuria; Diabetic Nephropathy; nephrology; Urologi; nefrologi;

   Abstract : To the extent that increased urinary protein excretion is an indicator of alterations of the glomerular capillary wall (GCW) and appearance of tubulointerstitial damage, proteinuria can be a good marker of the overall severity of the glomerular and tubulointerstitial damage, and therefore, the prognosis of glomerular diseases. Studies I, II, and III show that it is the type of proteinuria, rather than the degree of albuminuria, that predicts the progression in renal, proteinuric diseases. READ MORE