Search for dissertations about: "diazoxide"
Showing result 1 - 5 of 15 swedish dissertations containing the word diazoxide.
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1. Pulsatile insulin release from single islets of Langerhans
Abstract : Insulin release from single islets of Langerhans is pulsatile. The secretory activities of the islets in the pancreas are coordinated resulting in plasma insulin oscillations. Nutrients amplitude-regulate the insulin pulses without influencing their frequency. READ MORE
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2. Effects of over-stimulation by glucose on pancreatic beta-cell functioning : studies in vitro with diazoxide
Abstract : Long term hyperglycemia impairs pancreatic ß-cell function. In vivo studies in rats have shown a decreased glucose-induced insulin response in the perfused pancreas after high glucose infusions. READ MORE
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3. Aspects on the modulation of potassium channels in insulin-producing beta-cells
Abstract : This thesis attempts to further clarify mechanisms behind the negative effects of overstimulation and the beneficial effect of β-cell rest. For this purpose diazoxide - opener of K+-ATP channels, which reversibly inhibits glucose-induced insulin secretion, was used as a probe. READ MORE
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4. The importance of immunological, genetic and clinical factors for beta cell function in childhood diabetes
Abstract : Type I diabetes is caused by environmentally initiated, progressive autoimmune destruction of pancreatic beta cells in genetically susceptible individuals, which results in insulin deficiency and hyperglycemia. At diagnosis, about 10-20 % of beta cells remain, but after insulin therapy is started, a period with regained secretive capacity follows. READ MORE
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5. Endocrine aspects of obesity and weight reduction by bariatric surgery : with special emphasis on beta cell function
Abstract : Severe obesity is the most predictive acquired risk factor for the development of type 2 diabetes. Bariatric surgery induces marked weight loss and reverses the diabetic state significantly. READ MORE
