Search for dissertations about: "diffusion release"

Showing result 1 - 5 of 129 swedish dissertations containing the words diffusion release.

2. 1. Poly(Lactide-co-Glycolide) in Controlled-Release Pharmaceuticals - Release Mechanisms

   Author : Susanne Fredenberg; Avdelningen för kemiteknik; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; PLGA; Poly lactide-co-glycolide ; Release mechanism; Diffusion; Controlled Release; Degradation; Protein;

   Abstract : Controlled-release formulations reduce the frequency of injections and better maintain plasma concentrations within the therapeutic window. Poly(D,L-lactide-co-glycolide) (PLG) is currently the most frequently used biodegradable polymer for this application. READ MORE

4. 2. Modelling of Drug Release from Reservoir and Matrix Formulations - Multiple Unit Dosage Forms and Swelling and Dissolving Matrix Systems

   Author : Per Borgquist; Avdelningen för kemiteknik; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; swelling; XEDS; Chemical technology and engineering; Kemiteknik och kemisk teknologi; Polymer technology; biopolymers; Polymerteknik; Pharmaceutical and related technologies; Läkemedelsteknik och relaterad teknik; simulation; single pellet; single-unit release; SEM; reservoir system; poly ethylene oxide ; film-coated; matrix; mathematical model; diffusion; pellet shape; controlled release; polymer dissolution; modelling; ethyl cellulose; Coating; multiple-unit release;

   Abstract : In this work, mathematical models have been developed describing drug release from film-coated reservoir systems as well as drug release and polymer dissolution from swelling and dissolving polymer tablets. The model derivation of both systems is based on a mechanistic approach. The model describing drug release from reservoir systems, i.e. READ MORE

5. 3. Characterization of the Mechanisms of Drug Release from Polymer-Coated Formulations using Experiments and Modelling

   Author : Mariagrazia Marucci; Avdelningen för kemiteknik; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; ethyl cellulose; Release mechanism; coating; polymer blend; modelling; ESPI; diffusion; osmotic pumping; SEM; single pellet; CLSM; hydroxypropyl cellulose; multiple-unit release;

   Abstract : The main objectives of the work presented in this thesis were to develop new experimental methods to improve the understanding of the release mechanism from a coated formulation and to develop new mechanistic models to describe the release process for pellets coated with a semi-permeable film. Another aim was to characterize the release mechanism from a formulation coated with films made of a blend of a water-insoluble polymer, ethyl cellulose (EC), and a water-soluble polymer, hydroxypropyl cellulose (HPC). READ MORE

6. 4. Prolonged Drug Release from Gels, using Catanionic Mixtures

   Author : Tobias Bramer; Katarina Edsman; Per Hansson; Stefan Ulvenlund; Uppsala universitet; []
   Keywords : Pharmaceutics; gel; catanionic; vesicle; micelle; controlled release; diffusion; surfactant; drug delivery; Galenisk farmaci;

   Abstract : The use of catanionic drug-surfactant mixtures was proven to be an efficient novel method of obtaining prolonged drug release from gels. It was shown that various commonly used drug compounds are able to form catanionic mixtures together with oppositely charged surfactants. READ MORE

7. 5. Drug Diffusion and Nano Excipient Formation Studied by Electrodynamic Methods

   Author : Ulrika Brohede; Maria Strømme; Göran Frenning; Hans Leuenberger; Uppsala universitet; []
   Keywords : Functional materials; drug release; electrodynamic methods; diffusion; Funktionella material;

   Abstract : New smart drugs demand new smart drug delivery systems and also new smart analysis methods for the drug delivery process and material characterization. This thesis contributes to the field by introducing a new electrodynamic approach for studying the drug diffusion proc-esses as well as the formation of a new type of drug delivery systems, the so called mesoporous nano excipients. READ MORE