Search for dissertations about: "disease gene"

Showing result 1 - 5 of 880 swedish dissertations containing the words disease gene.

  1. 1. A peripheral immune response in Huntington's disease and delineation of its importance in disease pathology

    University dissertation from Lund University (Media-Tryck)

    Author : Anna Magnusson-Lind; Lunds universitet.; Lund University.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington s disease; peripheral symptoms; immune response; muscle atrophy; cytokines; gene expression; JAK STAT; NFkB; IL-6; TNF-alpha;

    Abstract : Popular Abstract in Swedish Huntingtons sjukdom (HS) är en ärftlig hjärnsjukdom utan botemedel. Den orsakas av en mutation i en gen som kallas huntingtin. Den klassas som en s.k. READ MORE

  2. 2. Genetic Variations in Type 2 Diabetes and Cardiovascular Disease: A Focus on Gene-Lifestyle Interactions and Mendelian Randomization

    University dissertation from Diabetes and cardiovascular disease - genetic epidemiology

    Author : George Hindy; Lunds universitet.; Lund University.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; cardiovascular disease; coronary heart disease; metabolic syndrome; genetics; gene-lifestyle interactions; diet; TCF7L2; WNT signaling; chromosome 9p21; Mendelian randomization;

    Abstract : Popular Abstract in English The prevalence of type 2 diabetes (T2D) and cardiovascular disease (CVD) is increasing in epidemic proportions around the globe. This epidemic accounts for huge health and economic burdens as a leading cause for morbidity and mortality. READ MORE

  3. 3. Polyglandular Autoimmune (PGA) Syndromes and associations to sarcoidosis

    University dissertation from Department of Endocrinology, Wallenberg laboratory, Malmö University Hospital

    Author : Konstantinos I Papadopoulos; Lunds universitet.; Lund University.; [1999]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiotensin converting enzyme ACE ; DQB1; DRB1; HLA; H K ATPase; antigliadin; autoantibodies; pernicious anaemia; coeliac disease; sarcoidosis; Hashimoto thyroiditis; Graves disease; autoimmune thyroid disease; Addison s disease; Polyglandular autoimmune PGA syndromes; autoimmunity; ACE gene polymorphism; Immunology; serology; transplantation; Immunologi; serologi;

    Abstract : Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING (Svenska) I en klassisk monografi från 1855 med titel ”On the Constitutional and Local Effects of Disease of the Suprarenal Capsules” beskrev T. Addison det tillstånd som numera bär på hans namn. READ MORE

  4. 4. Brown is the new white: consequences of white adipose tissue alterations in Huntington's disease

    University dissertation from Lund University, Faculty of Medicine

    Author : Andy Mccourt; Lunds universitet.; Lund University.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington’s disease; weight loss; white adipose tissue; brown adipose tissue; peripheral symptoms; R6 2 mice; UCP1; CREB1; gene expression;

    Abstract : Huntington's disease (HD) is a devastating, inherited neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. Peripheral symptoms, such as skeletal muscle wasting, progressive weight loss, altered body composition and endocrine disturbances exist alongside neurodegeneration. READ MORE

  5. 5. Cell and gene therapy for blood disorders. Modeling of novel treatment strategies for Gaucher type 1 disease and Diamond-Blackfan anemia in mice

    University dissertation from Division of Molecular Medicine and Gene Therapy

    Author : Maria Dahl; Lunds universitet.; Lund University.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gaucher disease; lentiviral vectors; gene therapy; Diamond-Blackfan anemia; hematopoietic stem cells; bone marrow transplant; Schlafen-2;

    Abstract : Gaucher disease type 1 (GD type 1) and Diamond-Blackfan anemia (DBA) are rare genetic disorders affecting the hematopoietic system and routinely treated by administration of drugs with variable clinical efficacy. Though effective in alleviating disease symptoms in large cohorts of patients, these treatment options have the major drawback of being non-curative. READ MORE