Search for dissertations about: "disease gene"

Showing result 1 - 5 of 869 swedish dissertations containing the words disease gene.

  1. 1. Genetic Variations in Type 2 Diabetes and Cardiovascular Disease: A Focus on Gene-Lifestyle Interactions and Mendelian Randomization

    University dissertation from Diabetes and cardiovascular disease - genetic epidemiology

    Author : George Hindy; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cardiovascular disease; Type 2 diabetes; coronary heart disease; metabolic syndrome; genetics; gene-lifestyle interactions; diet; TCF7L2; WNT signaling; chromosome 9p21; Mendelian randomization;

    Abstract : Type 2 diabetes (T2D) and cardiovascular disease (CVD) are highly prevalent complex diseases that result from lifestyle and genetic factors. Gene-lifestyle interactions are also believed to contribute to the etiology of these diseases. READ MORE

  2. 2. A peripheral immune response in Huntington's disease and delineation of its importance in disease pathology

    University dissertation from Media-Tryck

    Author : Anna Magnusson-Lind; Lunds universitet.; Lund University.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peripheral symptoms; Huntington s disease; immune response; muscle atrophy; cytokines; gene expression; JAK STAT; NFkB; IL-6; TNF-alpha;

    Abstract : Huntington’s disease (HD) is a fatal, hereditary disease for which there is no cure. It is caused by a mutation in a gene called huntingtin. HD is a so-called neurodegenerative disease, where there is a loss of neurons in areas of the brain that control body movements. This results in uncontrolled dance-like movements (chorea). READ MORE

  3. 3. Polyglandular Autoimmune (PGA) Syndromes and associations to sarcoidosis

    University dissertation from Department of Endocrinology, Wallenberg laboratory, Malmö University Hospital

    Author : Konstantinos I Papadopoulos; Lunds universitet.; Lund University.; [1999]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DQB1; angiotensin converting enzyme ACE ; DRB1; HLA; H K ATPase; antigliadin; autoantibodies; pernicious anaemia; coeliac disease; sarcoidosis; Hashimoto thyroiditis; Graves disease; autoimmune thyroid disease; Addison s disease; Polyglandular autoimmune PGA syndromes; autoimmunity; ACE gene polymorphism; Immunology; serology; transplantation; Immunologi; serologi;

    Abstract : Polyglandular Autoimmune (PGA) syndrome type II in idiopathic Addison's disease: In a retrospective study of idiopathic Ad-dison's disease (median age at diagnosis 32.5 years, range 8-62; median observation time 17 years, range 0.5-41), 50% met the criteria for PGA syndrome type II. In PGA syndrome type II, 73% had ATD and 41% had IDDM. READ MORE

  4. 4. Gene Therapy for Neurological Disorders

    University dissertation from Lund University, Faculty of Medicine

    Author : Jan Tönnesen; Lunds universitet.; Lund University.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; striatum; epileptiform activity; organotypic culture; electrophysiology; Wnt5a; synaptic connectivity.; cell transplantation; hippocampus; neural stem cells; epilepsy; functional integration; Parkinson’s disease; optogenetics; Gene therapy;

    Abstract : Gene therapy is an attractive strategy for neurological disorders, such as Parkinson’s disease and epilepsy, for several reasons. Introduction of genes with a therapeutic potential can be achieved locally, by accurate injections in the compromised tissue, and release of a transgene therapeutic substance can be regulated by the surrounding host neural circuitry. READ MORE

  5. 5. Topics in Human Gene Mapping

    University dissertation from Mathematical Statistics, Centre for Mathematical Sciences, Lund University

    Author : Azra Kurbasic; Lunds universitet.; Lund University.; [2007]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Statistik; actuarial mathematics; programming; Statistics; Mathematics; Naturvetenskap; Natural science; hidden Markov model; linkage analysis; Human genome; disease gene; programmering; aktuariematematik; operationsanalys; operations research; Matematik;

    Abstract : This thesis is interdisciplinary between Mathematical Statistics, Genetics, and Medicine. It mainly consists of topics in mathematical modelling of the correlation of inheritance of genes and disease in a family, a method called linkage analysis. It is organized as follows. READ MORE