Search for dissertations about: "dissertations cancer of brain in children"

Showing result 1 - 5 of 6 swedish dissertations containing the words dissertations cancer of brain in children.

  2. 1. Of Mice and MYC : Modelling Medulloblastoma

    Author : Oliver Mainwaring; Fredrik J. Swartling; Charles Eberhart; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medulloblastoma; MYC; Group 3; Cdkn2a; ARF; HSP90; Chromosome 17q; Medicinsk vetenskap; Medical Science; Oncology; Onkologi;

    Abstract : Brain tumours are the leading cause of cancer-related paediatric deaths, with medulloblastoma (MB) being the most common malignant paediatric brain tumour. MB is stratified into four major subgroups – WNT, SHH, Group 3, and Group 4, nomenclature defined by key pathways and drivers involved within each subgroup. READ MORE

  4. 2. Modeling and investigations of high-grade glioma to understand tumorigenesis and heterogeneity

    Author : Nagaprathyusha Maturi; Lene Uhrbom; Helena Carén; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioblastoma; diffuse pediatric-type high-grade glioma; cell of origin; heterogeneity; serum culture; glioblastoma stem cell; chromatin accessibility; cross-species conservation; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : Glioblastoma (GBM) is the most common primary malignant brain tumor. As per 2021 WHO classification, the corresponding diagnosis in children is called diffuse pediatric-type high-grade glioma (pHGG). In both cases tumors are histone 3 (H3) and isocitrate dehydrogenase 1/2 (IDH1/2) wildtype (wt). READ MORE

  5. 3. Graph theory based approaches for gene prioritization in biological networks : Application to cancer gene detection in medulloblastoma

    Author : Hrafn Holger Weishaupt; Sergei Silvestrov; Erik Bongcam-Rudloff; Mälardalens högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mathematics Applied Mathematics; matematik tillämpad matematik;

    Abstract : Networks provide an intuitive and highly adaptable means to model relationships between objects. When translated to mathematical graphs, they become further amenable to a plethora of mathematical operations that allow a detailed study of the underlying relational data. READ MORE

  6. 4. Application of Genomic and Expression Arrays for Identification of new Cancer Genes

    Author : Helena Nord; Teresita Díaz de Ståhl; Jan Dumanski; Susan Pfeifer; Blomquist Erik; Segersten Ulrika; David Gisselsson Nord; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Array-CGH; Expression array; Copy number variation; Glioblastoma; Medulloblastoma; Bladder carcinoma; Oncogenes; Tumor suppressor genes; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Medical genetics; Medicinsk genetik; Tumour biology; Tumörbiologi; Genetics; Genetik; Medical Genetics; Medicinsk genetik;

    Abstract : Copy number variation (CNV) comprises a recently discovered kind of variation involving deletion and duplication of DNA segments of variable size, ranging from a few hundred basepairs to several million. By altering gene dosage levels or disrupting proximal or distant regulatory elements CNVs create human diversity. READ MORE

  7. 5. Malignancies in Sweden after the Chernobyl accident in 1986

    Author : Martin Tondel; Bodil Persson; Lennart Hardell; Bengt Järvholm; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epidemiology; Environmental; Chernobyl; ionising radiation; geographical information systems GIS; 8-OHdG; Malignancies; Low dose; Dose-response; Latency; Causalty; Epidemiology; Epidemiologi;

    Abstract : On 26 April 1986 an accident occurred in the Chernobyl nuclear power plant resulting in the release of large amount of radionuclides. Almost five percent of the total released caesium-137 was deposited in Sweden. The incidence of malignancies in the most affected counties in Sweden was investigated in three epidemiological studies. READ MORE