Search for dissertations about: "dissertations cytotoxicity"

Showing result 1 - 5 of 101 swedish dissertations containing the words dissertations cytotoxicity.

  2. 1. Mechanisms involved in amyloid induced cytotoxicity

    Author : Johan Östman; Lars Lannfelt; Umeå universitet; []
    Keywords : amyloid; transthyretin; cytotoxicity; apoptosis; caspases; aggregation; molekylärbiologi; Molecular Biology;

    Abstract : Amyloidoses comprise a group of diseases where normal or mutated protein precipitates into amyloid fibrils. The deposition of fibrils causes dysfunction of organs and toxicity to nervous tissue. Up to date, 24 different proteins and peptides are known to be able to form amyloid fibrils. READ MORE

  4. 2. Structural studies of heterogeneous amyloid species of lysozymes and de novo protein albebetin and their cytotoxicity

    Author : Vladimir Zamotin; Ludmilla Morozova-Roche; Daniel Otzen; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; amyloid; cytotoxicity; atomic force microscopy; Biophysics; Biofysik;

    Abstract : A number of diseases are linked to protein folding problems which lead to the deposition of insoluble protein plaques in the brain or other organs. These diseases include prion diseases such as Creutzfeld-Jakob disease, Alzheimer's disease, Parkinson's disease and type II (non-insulin dependent) diabetes. READ MORE

  5. 3. Amyloids here, amyloids there…What’s wrong with them?

    Author : Anna Gharibyan; Ludmilla Morozova-Roche; Tuomas Knowels; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyloids; oligomers; fibrils; cytotoxicity; Alzheimer s disease; Aortic stenosis; S100A9; medicinsk biokemi; Medical Biochemistry;

    Abstract : Amyloid formation is inherent property of proteins which under certain circumstances can become a pathologic feature of a group of diseases called amyloidosis. There are about 30 known human amyloidosis and more than 27 identified proteins involved in these pathologies. READ MORE

  6. 4. Human intestinal T lymphocytes : a comparative analysis of phenotype and function in normal and inflamed mucosa

    Author : Silvia Melgar; Nadine Cerf-Bensussan; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human intestinal mucosa; intraepithelial lymphocyte; lamina propria lymphocyte; γδ T cell; regulatory T cell; cytotoxicity; cytokine; basal lymphoid aggregate; ulcerative colitis; Crohn s disease;

    Abstract : The epithelial lining of the gut must allow immediate contact with beneficial components as nutrients and normal microflora. At the same time it runs the constant risk of attack from pathogenic microbes and noxious agents. READ MORE

  7. 5. The amyloid : structure, properties and application

    Author : Mantas Malisauskas; Ludmilla Morozova-Roche; Fabrizio Chiti; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; oligomers; AFM; cytotoxicity; biotemplating; lysozyme; Biochemistry; Biokemi;

    Abstract : Protein aggregation, leading to the formation and depositions of amyloids, is a cause for a number of diseases such as Alzheimer’s and Creutzfeld-Jacob’s disease, systemic amyloidoses, type II diabetes and others . More than 20 proteins are associated with protein misfolding diseases and even a larger number of proteins can self-assemble into amyloid in vitro. READ MORE