Search for dissertations about: "distal lung"

Showing result 1 - 5 of 28 swedish dissertations containing the words distal lung.

  2. 1. Charting the human lung with inhaled nanoparticles : Development of AiDA - a new diagnostic technique for respiratory disease

    Author : Jonas Jakobsson; NanoLund: Centre for Nanoscience; []
    Keywords : Aerosol; lung; lung deposition; respiratory tract; nanoparticles; ultrafine particles; airspace dimension assessment; AiDA; Chronic obstructive pulmonary disease; COPD; lung morphology;

    Abstract : Changes to the smallest structures of the distal lung are often the first sign of severe respiratory disease, but to date methods to detect and quantify these changes are limited. Chronic obstructive pulmonary disease (COPD) is currently estimated to be the third most common cause of death worldwide, but is to a large extent under-diagnosed, especially at early stages. READ MORE

  4. 2. Mesenchymal heterogeneity in the adult human lung

    Author : Måns Kadefors; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lung; Extracellular matrix; Adventitia; Fibroblast; mesenchymal cell; Alveolar epithelial cell; Fibrosis; Idiopathic pulmonary fibrosis; Mass spectrometry; RNA-sequencing;

    Abstract : The human lung is a complex tissue consisting of a heterogeneous mix of different structures and cells, each which a specific role that together contribute to the primary function of the organ: the gas exchange. Different mesenchymal cells populate the interstitial areas around airways and blood vessels and form the connective tissue together with the extracellular matrix. READ MORE

  5. 3. Mechanisms of Lung Injury in a Mouse Model of Bronchopulmonary Dysplasia

    Author : Anna Hogmalm; Göteborgs universitet; []
    Keywords : bronchopulmonary dysplasia; transgenic mice; inflammation; lung; interleukin-1; αvβ6 integrin; mmp-9; surfactant;

    Abstract : Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects preterm infants. Increased levels of inflammatory mediators in the amniotic fluid and in the lungs of preterm infants are associated with the development of BPD. READ MORE

  6. 4. Structure of the distal lung studied with inhaled nanoparticles

    Author : Madeleine Petersson Sjögren; Metalund; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Techniques able to detect impairments in the distal human lung are lacking. Since inhaled nanoparticles are predominantly deposited in the acini, their deposition can be used to derive structural properties of the region. Intheory, structural enlargements in the distal lung imply that less inhaled nanoparticles deposit there. READ MORE

  7. 5. Lung growth and lung hypoplasia in congenital diaphragmatic hernia

    Author : Carmen Mesas Burgos; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Pulmonary hypoplasia and persistent pulmonary hypertension are the main causes of mortality and morbidity in newborns with congenital diaphragmatic hernia (CDH). Prenatal tracheal occlusion or ligation (TL) is known to accelerate lung growth, but the mechanism of this is poorly understood. READ MORE