Search for dissertations about: "dna: chemistry"
Showing result 1 - 5 of 284 swedish dissertations containing the words dna: chemistry.
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1. Modeling DNA Damage
Abstract : In this thesis methods of computational chemistry have been used to examine DNA damaging processes initiated by ionizing radiation, free radicals, or Low-Energy Electrons (LEE). The computational chemistry method based on quantum mechanics that has been mainly used here is the Density Functional Theory (DFT). READ MORE
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2. Redefining the essential molecular aspects that drive interactions between small molecules and G-quadruplex DNA
Abstract : G-Quadruplex (G4) structures are secondary nucleic acid structures located in guanine-rich regions of DNA and RNA sequences, involved in gene regulation and cellular maintenance. Efforts to target G4s in a therapeutic setting are scarce, mainly due to vague details about the binding interactions between the ligands and the G4 structure combined with the lack of emphasis on drug-like properties early in the ligand development process. READ MORE
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3. DNA Compaction at Surfaces
Abstract : The interfacial behavior of DNA and DNA-cationic surfactant has been studied. Particular attention was paid to the type of cationic surfactant and the DNA conformation (single or double stranded) as well as the DNA length. READ MORE
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4. Fluorescent DNA Modifications for Use as Probes of Biological Structure and as Nanotechnological Functional Units
Abstract : .... READ MORE
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5. Condensation of DNA for Gene Delivery: Studies on Vector-Nucleic Acid Interactions and Transfection Efficiency
Abstract : This thesis concerns the delivery of nucleic acids into cells and tissues with the aim to change or correct gene expression. The field of gene delivery has the ultimate goal of producing genetic drugs for clinical applications, and the activity in this area is intense although so far the use is limited to research purposes. READ MORE