Search for dissertations about: "domain repeats"

Showing result 1 - 5 of 46 swedish dissertations containing the words domain repeats.

2. 1. Variation in length of proteins by repeats and disorder regions

   Author : Rauan Sagit; Arne Elofsson; Andrey Kajava; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein length; repeats; domain repeats; protein evolution; duplication; tandem duplication; intrinsic disorder; intrinsically disordered; variation in length; insertion; deletion; recombination; expansion; contraction; Biochemistry; biokemi;

   Abstract : Protein-coding genes evolve together with their genome and acquire changes, some of which affect the length of their protein products. This explains why equivalent proteins from different species can exhibit length differences. READ MORE

4. 2. Leucine-rich repeats and immunoglobulin-like domain (LRIG) proteins : possible prognostic markers in vulvar squamous cell carcinoma, endometrial carcinoma, and oropharymgeal squamous cell carcinoma

   Author : Husam Oda; David Lindquist; Eva Lundin; Ulrika Ottander; Kristina Stefansson; Kate Cuschieri; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vulvar squamous cell carcinoma; endometrial carcinoma; oropharyngeal squamous cell carcinoma; LRIG1-3; HPV; LMO7; HPV-driven; non-HPV-driven; prognosis; overall survival; disease-free survival; p53; Ki-67; CD8 TILs; CD44.; Pathology; patologi;

   Abstract : The human leucine-rich repeats and immunoglobulin-like domain (LRIG) gene family comprises three genes, LRIG1, LRIG2 and LRIG3, which encode the LRIG1, LRIG2 and LRIG3 proteins, respectively. Previous stidies have revealed the different prognostic roles of these proteins in different cancers, and it has been shown that LRIG1 functions as a tumour suppressor in certain cancers via its negative regulation of several receptor tyrosine kinases. READ MORE

5. 3. Domain rearrangement and creation in protein evolution

   Author : Diana Ekman; Arne Elofsson; Christine Orengo; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioinformatics; Bioinformatik; Biochemistry; biokemi;

   Abstract : Proteins are composed of domains, recurrent protein fragments with distinct structure, function and evolutionary history. Some domains exist only as single domain proteins, however, a majority of them are also combined with other domains. READ MORE

6. 4. Creation of new proteins - domain rearrangements and tandem duplications

   Author : Åsa Björklund; Arne Elofsson; Sarah Teichmann; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioinformatics; Bioinformatik; Biochemistry; biokemi;

   Abstract : Proteins are modular entities with domains as their building blocks. The domains are recurrent protein fragments with a distinct structure, function and evolutionary history. During evolution, proteins with new functions have been invented through rearrangements as well as differentiation of domains. READ MORE

7. 5. THE ANDROGEN RECEPTOR GGN POLYMORPHISM. Genetic and functional analyses

   Author : Kristina Lundin; Avdelningen för klinisk genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; Functional domain; Genetic predisposition; Reproductive function; Sex hormone; Transactivation function; Repeat; Polymorphism; Androgen receptor; Transcription factor; Medicin människa och djur ; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

   Abstract : Male sex development and reproductive function is regulated by androgens acting via the androgen receptor (AR). The AR harbours two polymorphic repeats of CAG and GGN triplets, encoding glutamines and glycines, respectively. READ MORE