Search for dissertations about: "dopamine D2 receptor"

Showing result 1 - 5 of 105 swedish dissertations containing the words dopamine D2 receptor.

  2. 1. Dopamine D2 and D3 receptors. Studies on transduction mechanisms and on the role of a D3 gene polymorphism

    Author : Monika Hellstrand; Göteborgs universitet; []
    Keywords : dopamine; dopamine D2 receptor; dopamine D3 receptor; transduction; CHO cells; partial agonism; inverse agonism; arachidonic acid; prostaglandin E2; cAMP; haloperidol; -3-PPP; PNU-99194A; polymorphism; personality;

    Abstract : The neurotransmitter dopamine has been implicated in the pathophysiology of, e.g., Parkinson s disease and schizophrenia, and dopamine receptor-active compounds are commonly employed therapeutically in these and other disorders. READ MORE

  4. 2. Aerobic fitness and healthy brain aging : cognition, brain structure, and dopamine

    Author : Lars Jonasson; Carl-Johan Boraxbekk; Katrine Riklund; Emrah Düzel; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aerobic exercise; VO2; working memory; executive function; freesurfer; striatum; dopamine; D2-receptors; [11C]raclopride;

    Abstract : Background: Performing aerobic exercise and maintaining high levels of aerobic fitness may have positive effects on both brain structure and function in older adults. Despite decades of research however, there is still a rather poor understanding of the neurocognitive mechanisms explaining the positive effects of aerobic exercise on cognition. READ MORE

  5. 3. Selectivity of dopamine D1 and D2 receptor agonists – A combined computational approach

    Author : Marcus Malo; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; dopamine; agonists; GPCRs; pharmacophore modeling; protein structure modeling; agonist selectivity;

    Abstract : Dopamine (DA) is an endogenous neurotransmitter acting in the central nervous system. DA plays a key role in many vital brain functions such as behavior, cognition, motor activity, learning, and reward. Dopamine receptors belong to the rhodopsin like family of G-protein coupled receptors (GPCRs). READ MORE

  6. 4. Dopamine D2 and D3 receptor-ligand interactions : molecular pharmacology and medicinal chemistry

    Author : Åsa Malmberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  7. 5. PET applications in schizophrenia : Functional and pharmacological dopamine studies

    Author : Ola Gefvert; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Schizophrenia; PET; dopamine synthesis rate; dopamine D2 receptor occupancy; atypical antipsychotics; quetiapine; risperidone microsphere depot; Neurovetenskap; Neurology; Neurologi; Psychiatry; psykiatri;

    Abstract : Schizophrenia is a group of disorders with a worldwide lifetime prevalence of 0.85%. Thefunctional outcome of the disorder seem stable from the first systematic outcome studies to thepresent day, and vary only with changes in diagnostic criteria. READ MORE