Search for dissertations about: "double-stranded dna"

Showing result 1 - 5 of 88 swedish dissertations containing the words double-stranded dna.

  2. 1. Repair of DNA double-stranded breaks in human cells

    Author : Susanne Nyström; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA-PK; DNA double-stranded break; DSB; DNA single-stranded break; SSB; DNA damage; ionizing radiation; IR; DNA repair; calicheamicin gamma1; bleomycin; etoposide; topoisomerase II; radiotherapy; radiosensitizer; ATM;

    Abstract : DNA is continuously subjected to degradation. Therefore, our cells need to constantly repair its DNA to prevent mutations and in the long run cancer. In mammalian cells, when DNA is broken right off, a double-stranded break (DSB) is produced, and the ends are ligated by a process called non-homologous end-joining (NHEJ). READ MORE

  4. 2. DNA Compaction at Surfaces

    Author : Marité Cárdenas; Fysikalisk kemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Polymer technology; Fysikalisk kemi; Physical chemistry; gränsskikt; Ytkemi; Surface and boundary layery chemistry; cationic amphiphiles; DNA; Polymerteknik; surface; biopolymers;

    Abstract : The interfacial behavior of DNA and DNA-cationic surfactant has been studied. Particular attention was paid to the type of cationic surfactant and the DNA conformation (single or double stranded) as well as the DNA length. READ MORE

  5. 3. Sensitive Forensic DNA Analysis : Application of Pyrosequencing and Real-time PCR Quantification

    Author : Hanna Andréasson; Marie Allen; Ulf Gyllensten; Pål Nyrén; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; forensic; sensitive DNA analysis; DNA quantification; mtDNA; Real-time PCR; Pyrosequencing; Genetik; Clinical genetics; Klinisk genetik;

    Abstract : The field of forensic genetics is growing fast and the development and optimisation of more sensitive, faster and more discriminating forensic DNA analysis methods is highly important. In this thesis, an evaluation of the use of novel DNA technologies and the development of specific applications for use in forensic casework investigations are presented. READ MORE

  6. 4. Overstretching short DNA – Single-molecule force spectroscopy studies

    Author : Niklas Bosaeus; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; DNA stretching; mechanical properties of DNA; single molecule; optical tweezers; DNA structure;

    Abstract : Structural deformation of DNA has a central role in many biological processes. It occurs, for example, during replication, transcription, and regulation of the activity of the genome. To understand these fundamental processes it is necessary to have a detailed knowledge of the mechanical properties of DNA. READ MORE

  7. 5. Structure of eukaryotic DNA polymerase epsilon and lesion bypass capability

    Author : Nasim Sabouri; Erik Johansson; Lars Thelander; Ola Hammarsten; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; DNA polymerase epsilon; DNA replication; Okazaki fragment; Translesion synthesis; DNA lesion; dNTP; Biochemistry; Biokemi;

    Abstract : To transfer the information in the genome from mother cell to daughter cell, the DNA replication must be carried out only once and with very high fidelity prior to every cell division. In yeast there are several different DNA polymerases involved in DNA replication and/or DNA repair. READ MORE