Search for dissertations about: "droplet-based system"

Found 3 swedish dissertations containing the words droplet-based system.

  2. 1. Barcoded DNA Sequencing for Parallel Protein Detection

    Author : Mahya Dezfouli; Afshin Ahmadian; Ulf Landegren; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA barcoding; antibody labeling; antibody oligonucleotide bio-conjugation; DNAassisted proteomics; immuno-sequencing I-Seq ; droplet-based system; large-scale data analysis; Biotechnology; Bioteknologi;

    Abstract : The work presented in this thesis describes methodologies developed for integration and accurate interpretation of barcoded DNA, to empower large-scale-omics analysis. The objectives mainly aim at enabling multiplexed proteomic measurements in high-throughput format through DNA barcoding and massive parallel sequencing. READ MORE

  4. 2. Silicon Nanoribbon FET Sensors : Fabrication, Surface Modification and Microfluidic Integration

    Author : Roodabeh Afrasiabi; Jan Linnros; Michel Calame; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Informations- och kommunikationsteknik; Information and Communication Technology;

    Abstract : Over the past decade, the field of medical diagnostics has seen an incredible amount of research towards the integration of one-dimensional nanostructures such as carbon nanotubes, metallic and semiconducting nanowires and nanoribbons for a variety of bio-applications. Among the mentioned one-dimensional structures, silicon nanoribbon (SiNR) field-effect transistors (FET) as electro-chemical nanosensors hold particular promise for label-free, real-time and sensitive detection of biomolecules using affinity-based detection. READ MORE

  5. 3. Perks and considerations when targeting functional non-coding regions with CRISPR/Cas9

    Author : Keyi Geng; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Since the CRISPR system was discovered as an adaptive immune response in prokaryotic cells, the past decade has witnessed the engineering and deployment of CRISPR/Cas9 as one of the most efficient and powerful molecular tools. By leveraging the nuclease activity of CRISPR/Cas9, researchers are able to probe the biological functions of genetic elements and dissect molecular interactions by disrupting, activating or inactivating genes. READ MORE