Search for dissertations about: "drug release"

Showing result 16 - 20 of 317 swedish dissertations containing the words drug release.

2. 16. Biopharmaceutical Evaluation of Intra-arterial Drug-Delivery Systems for Liver Cancer : Investigations in healthy pigs and liver cancer patients

   Author : Elsa Lilienberg; Hans Lennernäs; Erik Sjögren; Niklas Axén; Helen M. Burt; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in vivo release; drug delivery systems; local delivery; drug disposition; doxorubicin; hepatocellular carcinoma; transarterial chemoembolization; transarterial chemotherapy infusion; Pharmaceutical Science; Farmaceutisk vetenskap;

   Abstract : There are currently two types of intra-arterial drug-delivery system (DDS) in clinical use in the palliative treatment of primary liver cancer. The chemotherapeutic drug doxorubicin (DOX) can be formulated into a drug-in-lipiodol emulsion (LIPDOX) or a microparticulate drug-eluting bead system (DEBDOX). READ MORE

4. 17. Drug Diffusion and Nano Excipient Formation Studied by Electrodynamic Methods

   Author : Ulrika Brohede; Maria Strømme; Göran Frenning; Hans Leuenberger; Uppsala universitet; []
   Keywords : Functional materials; drug release; electrodynamic methods; diffusion; Funktionella material;

   Abstract : New smart drugs demand new smart drug delivery systems and also new smart analysis methods for the drug delivery process and material characterization. This thesis contributes to the field by introducing a new electrodynamic approach for studying the drug diffusion proc-esses as well as the formation of a new type of drug delivery systems, the so called mesoporous nano excipients. READ MORE

5. 18. Study on multifunctional smart drug delivery systems

   Author : Yunsuk Jo; KTH; []
   Keywords : Drug delivery systems; Poly lactic acid ; Poly N-isopropylacrylamide ; Controlled-release; Stimuli-sensitive polymer; Mathematical modeling; Self-assembly; Au nanoparticle; Shell-in-shell structure;

   Abstract : .... READ MORE

6. 19. Characterization of the Mechanisms of Drug Release from Polymer-Coated Formulations using Experiments and Modelling

   Author : Mariagrazia Marucci; Avdelningen för kemiteknik; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; ethyl cellulose; Release mechanism; coating; polymer blend; modelling; ESPI; diffusion; osmotic pumping; SEM; single pellet; CLSM; hydroxypropyl cellulose; multiple-unit release;

   Abstract : The main objectives of the work presented in this thesis were to develop new experimental methods to improve the understanding of the release mechanism from a coated formulation and to develop new mechanistic models to describe the release process for pellets coated with a semi-permeable film. Another aim was to characterize the release mechanism from a formulation coated with films made of a blend of a water-insoluble polymer, ethyl cellulose (EC), and a water-soluble polymer, hydroxypropyl cellulose (HPC). READ MORE

7. 20. Controlled release gel formulations and preclinical screening of drug candidates

   Author : Tofeeq Ur-Rehman; Gerhard Gröbner; Mikael Elofsson; Åsa Gylfe; Martin Malmsten; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; poloxamer; drug delivery; micellization; DMSO; calorimetry; NMR. in situ gelation; chitosan; preclinical pharmacokinetics; type III secretion inhibitors; Physical chemistry; Fysikalisk kemi; Pharmaceutics; galenisk farmaci;

   Abstract : Simple gel formulations may be applied to enhance the systemic and local exposure of potential compounds. The aim of this thesis is the development and characterization of controlled release formulations based on thermo-reversible poloxamer gels, which are suitable for novel drug delivery applications. READ MORE