Search for dissertations about: "drug resistance"

Showing result 21 - 25 of 554 swedish dissertations containing the words drug resistance.

  2. 21. Prescription – Pollution – Poo – Pandemics - Priorities : Neuraminidase Inhibitors from an Environmental Resistance Development Perspective

    Author : Marie Nykvist; Josef D. Järhult; Mikael Leijon; Uppsala universitet; []
    Keywords : Influenza A virus; neuraminidase inhibitor; resistance; environmental; Mallard; zanamivir; avian influenza;

    Abstract : The natural Influenza A virus (IAV) host is waterfowl. Human IAV is treated with neuraminidase inhibitors (NAIs), which are stockpiled worldwide in case of an IAV pandemic. As the drugs escape regular waste water treatment, they can be detected in river waters. READ MORE

  4. 22. Modelling the evolution of treatment-induced resistance in Ph+ leukaemias

    Author : Jonathan Lindström; Ran Friedman; Arne Traulsen; Linnéuniversitetet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chronic myeloid leukaemia; Stochastic modelling; Tyrosine kinase inhibitor; Drug resistance; Clonal evolution; Biomedical Sciences; Biomedicinsk vetenskap; Medicinsk kemi; Medical Chemistry;

    Abstract : Targeted therapies are a mainstay of modern cancer treatments. Rather than harming rapidly dividing cells in general, targeted therapies work by directly interfering with oncogenic molecular pathways present in a tumour. Consequently, a targeted therapy typically has less severe side effects. READ MORE

  5. 23. Copper-transporting proteins and their interactions with platinum-based anticancer substances

    Author : Maria Espling; Pernilla Wittung-Stafshede; Oleg Dmitriev; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cisplatin; Atox1; copper transport; anticancer drug; resistance; platinum; spectroscopy.; biologisk kemi; biological chemistry;

    Abstract :   Cisplatin (CisPt) is an important drug that is used against various cancers, including testicular, ovarian, lung, head, and neck cancer. However, its effects are limited by cellular resistance. READ MORE

  6. 24. Resistance to neuraminidase inhibitors in influenza A virus isolated from mallards

    Author : Goran Orozovic; Björn Olsen; Johan Lennerstrand; Sigvard Olofsson; Linnéuniversitetet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; influenza; mallards; neuraminidase; PCR; sequencing; mutation; oseltamivir; zanamivir; resistance; NAI; antivirals; pandemic; Virology; Virologi; Molecular biology; Molekylärbiologi; Bioinformatics; Bioinformatik; Zoonotisk ekologi; Zoonotic Ecology; Virology; Virologi; Biokemi; Biochemistry;

    Abstract : Influenza A virus belongs to the Orothomyxoviridae family of viruses and is one of the most common pathogens that cause infections of the respiratory tract. The aim of this thesis was to investigate if neuraminidase inhibitor (NAI) Tamiflu® (oseltamivir, OC) and Relenza® (zanamivir, ZA) - related resistance mutations exist in the neuraminidase (NA) gene of viruses collected from wild birds. READ MORE

  7. 25. Antibiotic use and respiratory pathogens with focus on Streptococcus pneumoniae in Tanzanian children

    Author : Matilda Emgård; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antimicrobial stewardship; Drug resistance; Bacterial; Drug prescribing; Infant; Pneumococcal conjugate vaccines; Streptococcus pneumoniae; Tanzania; Viruses;

    Abstract : This thesis describes the epidemiology of Streptococcus pneumoniae (pneumococci) and other respiratory pathogens after introduction of the 13-valent pneumococcal conjugate vaccine (PCV13) and further portrays antibiotic use in Tanzanian children. Pneumococci are a leading cause of pneumonia in children. READ MORE