Search for dissertations about: "drug structure"
Showing result 1 - 5 of 479 swedish dissertations containing the words drug structure.
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1. Protein structure prediction : Zinc-binding sites, one-dimensional structure and remote homology
Abstract : Predicting the three-dimensional (3D) structure of proteins is a central problem in biology. These computationally predicted 3D protein structures have been successfully applied in many fields of biomedicine, e.g. family assignments and drug discovery. READ MORE
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2. New Approaches to Studies of Paracellular Drug Transport in Intestinal Epithelial Cell Monolayers
Abstract : Studies of intestinal drug permeability have traditionally been performed in the colon-derived Caco-2 cell model. However, the permeability of these cell monolayers resembles that of the colon rather than that of the small intestine, which is the major site of drug absorption following oral administration. READ MORE
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3. Structure-aided design of antiviral drugs : Application of the method on HIV-1 protease and SIV reverse transcriptase
Abstract : Many efforts have been made to control the AIDS epidemic. Extensive studies have been done on the biology, biochemistry, and structural biology of HIV in the search for antiviral drugs. The viral-encoded enzymes reverse transcriptase and protease have been main targets for drug design. READ MORE
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4. Computational Modelling in Drug Discovery : Application of Structure-Based Drug Design, Conformal Prediction and Evaluation of Virtual Screening
Abstract : Structure-based drug design and virtual screening are areas of computational medicinal chemistry that use 3D models of target proteins. It is important to develop better methods in this field with the aim of increasing the speed and quality of early stage drug discovery. READ MORE
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5. Borrelia channel-forming proteins : structure and function
Abstract : Borrelia is a Gram-negative, corkscrew-shaped bacterium transmitted by infected ticks or lice. Borreliae are subdivided into pathogens of two diseases: Lyme disease, caused mainly by B. burgdorferi, B. afzelii and B. READ MORE