Search for dissertations about: "duloxetine"

Showing result 1 - 5 of 6 swedish dissertations containing the word duloxetine.

2. 1. On the efficacy and prescription of serotonin reuptake inhibitors

   Author : Alexander Lisinski; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antidepressants; antidepressive agents; major depressive disorder; selective serotonin reuptake inhibitor; serotonin and noradrenaline reuptake inhibitor; tricyclic antidepressant;

   Abstract : This thesis addresses several controversial issues regarding commonly used antidepressants, including selective serotonin reuptake inhibitors (SSRIs), serotonin and noradrenaline reuptake inhibitors (SNRIs), and tricyclic antidepressants (TCAs). To this end, patient-level data from 28 placebo-controlled trials on SSRIs and 13 corresponding trials on the SNRI duloxetine, were requested and obtained. READ MORE

4. 2. Chemoenzymatic Dynamic Kinetic Resolution of Functionalized Secondary Alcohols

   Author : Richard Lihammar; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES;

   Abstract : Dynamic kinetic resolution (DKR) is the combination of a kinetic resolution with an in situ racemization and is a powerful method for obtaining optically active compounds. In this thesis various secondary alcohols are transformed to their corresponding enantiomerically enriched acetates by employing immobilized lipases as resolution catalysts and transition metal complexes as racemization catalysts. READ MORE

5. 3. Asymmetric transformation of ß- and γ-functionalized alcohols : Study of combined ruthenium-catalyzed racemization and enzymatic resolution

   Author : Annika Träff; Jan-Erling Bäckvall; Reko Leino; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Kinetic resolution; dynamic kinetic resolution; kinetic asymmetric transformation; dynamic kinetic asymmetric transformation; enzyme catalysis; racemization; asymmetric synthesis; chlorohydrin; cyano acetate; amino alcohol; metalloenzyme; bifunctional catalytic system; Organic synthesis; Organisk syntes; organisk kemi; Organic Chemistry;

   Abstract : The major part of this thesis describes the asymmetric synthesis of β- and γ-amino alcohols through the combination of ruthenium catalyzed racemization and enzymatic kinetic resolution. The dynamic kinetic resolution, DKR, protocol for chlorohydrins was improved by employing Bäckvall’s catalyst, which is a base activated racemization catalyst, in combination with Burkholderia cepacia lipase. READ MORE

6. 4. Enzyme- and Transition Metal-Catalyzed Asymmetric Transformations : Application of Enzymatic (D)KR in Enantioselective Synthesis

   Author : Richard Lihammar; Jan-Erling Bäckvall; Wolfgang Kroutil; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Dynamic Kinetic Resolution; Kinetic Resolution; Enzyme Catalysis; Asymmetric Synthesis; organisk kemi; Organic Chemistry;

   Abstract : Dynamic kinetic resolution (DKR) is a powerful method for obtaining compounds with high optical purity. The process relies on the combination of a kinetic resolution with an in situ racemization. READ MORE

7. 5. Transition metal-catalyzed reduction of carbonyl compounds : Fe, Ru and Rh complexes as powerful hydride mediators

   Author : Elina Buitrago; Hans Adolfsson; Robert Morris; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Asymmetric catalysis; amino acid; N-heterocyclic carbene; iron; ruthenium; rhodium; mechanistic investigation; kinetic study; asymmetric transfer hydrogenation; hydrosilylation; organisk kemi; Organic Chemistry;

   Abstract : A detailed mechanistic investigation of the previously reported ruthenium pseudo-dipeptide-catalyzed asymmetric transfer hydrogenation (ATH) of aromatic ketones was performed. It was found that the addition of alkali metals has a large influence on both the reaction rate and the selectivity, and that the rate of the reaction was substantially increased when THF was used as a co-solvent. READ MORE